2-hydroxy-3-oxopropionate reductase

2-hydroxy-3-oxopropionate reductase
Identifiers
EC number	1.1.1.60
CAS number	9028-68-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) is an enzyme that catalyzes the chemical reaction

(R)-glycerate + NAD(P)+ $\rightleftharpoons$ 2-hydroxy-3-oxopropanoate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (R)-glycerate, NAD⁺, and NADP⁺, whereas its 4 products are 2-hydroxy-3-oxopropanoate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-glycerate:NAD(P)⁺ oxidoreductase. This enzyme is also called tartronate semialdehyde reductase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1YB4.

References

• Gotto AM, Kornberg HL (1961). "The metabolism of C₂ compounds in micro-organisms. 7. Preparation and properties of crystalline tartronic semialdehyde reductase". Biochem. J. 81 (2): 273–84. PMC 1243334. PMID 13900766.