4-hydroxybenzoate nonaprenyltransferase

4-hydroxybenzoate nonaprenyltransferase
Identifiers
EC number	2.5.1.39
CAS number	9030-77-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 4-hydroxybenzoate nonaprenyltransferase (EC 2.5.1.39) is an enzyme that catalyzes the chemical reaction

solanesyl diphosphate (nonaisoprenol diphosphate) + 4-hydroxybenzoate $\rightleftharpoons$ diphosphate + nonaprenyl-4-hydroxybenzoate

Thus, the two substrates of this enzyme are nonaisoprenol diphosphate and 4-hydroxybenzoate, whereas its two products are diphosphate and nonaprenyl-4-hydroxybenzoate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. This enzyme participates in ubiquinone biosynthesis.

Nomenclature

The systematic name of this enzyme class is solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase. Other names in common use include:

• nonaprenyl-4-hydroxybenzoate transferase,
• 4-hydroxybenzoate transferase,
• p-hydroxybenzoate dimethylallyltransferase,
• p-hydroxybenzoate polyprenyltransferase,
• p-hydroxybenzoic acid-polyprenyl transferase, and
• p-hydroxybenzoic-polyprenyl transferase.

(See also, the page on 4-hydroxybenzoate polyprenyltransferase).

References

• Kalen A, Appelkvist EL, Chojnacki T, Dallner G (1990). "Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver". J. Biol. Chem. 265 (2): 1158–64. PMID 2295606.