9-cis-epoxycarotenoid dioxygenase

9-cis-epoxycarotenoid dioxygenase
Identifiers
EC number	1.13.11.51
CAS number	199877-10-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

9-cis-epoxycarotenoid dioxygenase (EC 1.13.11.51, nine-cis-epoxycarotenoid dioxygenase, NCED, AtNCED3, PvNCED1, VP14) is an enzyme with systematic name 9-cis-epoxycarotenoid 11,12-dioxygenase.^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

(1) a 9-cis-epoxycarotenoid + O2 $\rightleftharpoons$ 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal

(2) 9-cis-violaxanthin + O2 $\rightleftharpoons$ 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al

(3) 9'-cis-neoxanthin + O2 $\rightleftharpoons$ 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al

9-cis-epoxycarotenoid dioxygenase contains iron(II).

References

1. Schwartz, S.H.; Tan, B.C.; Gage, D.A.; Zeevaart, J.A.; McCarty, D.R. (1997). "Specific oxidative cleavage of carotenoids by VP14 of maize". Science. 276 (5320): 1872–1874. doi:10.1126/science.276.5320.1872. PMID 9188535.
2. Tan, B.C.; Schwartz, S.H.; Zeevaart, J.A.; McCarty, D.R. (1997). "Genetic control of abscisic acid biosynthesis in maize". Proc. Natl. Acad. Sci. USA. 94 (22): 12235–12240. doi:10.1073/pnas.94.22.12235. PMC 23760. PMID 9342392.
3. Qin, X.; Zeevaart, J.A. (1999). "The 9-cis-epoxycarotenoid cleavage reaction is the key regulatory step of abscisic acid biosynthesis in water-stressed bean". Proc. Natl. Acad. Sci. USA. 96 (26): 15354–15361. doi:10.1073/pnas.96.26.15354. PMC 24823. PMID 10611388.
4. Thompson, A.J.; Jackson, A.C.; Symonds, R.C.; Mulholland, B.J.; Dadswell, A.R.; Blake, P.S.; Burbidge, A.; Taylor, I.B. (2000). "Ectopic expression of a tomato 9-cis-epoxycarotenoid dioxygenase gene causes over-production of abscisic acid". Plant J. 23 (3): 363–374. doi:10.1046/j.1365-313x.2000.00789.x. PMID 10929129.
5. Iuchi, S.; Kobayashi, M.; Taji, T.; Naramoto, M.; Seki, M.; Kato, T.; Tabata, S.; Kakubari, Y.; Yamaguchi-Shinozaki, K.; Shinozaki, K. (2001). "Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis". Plant J. 27 (4): 325–333. doi:10.1046/j.1365-313x.2001.01096.x. PMID 11532178.
6. Iuchi, S.; Kobayashi, M.; Taji, T.; Naramoto, M.; Seki, M.; Kato, T.; Tabata, S.; Kakubari, Y.; Yamaguchi-Shinozaki, K.; Shinozaki, K. (2002). "Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis". Plant J. 30: 611–611. doi:10.1046/j.1365-313X.2002.01347.x.

External links

• 9-cis-epoxycarotenoid dioxygenase at the US National Library of Medicine Medical Subject Headings (MeSH)