AMELY

AMELY
Identifiers
Aliases	AMELY, AMGL, AMGY, amelogenin, Y-linked
External IDs	OMIM: 410000 MGI: 88005 HomoloGene: 47996 GeneCards: AMELY
Gene ontology Molecular function • structural constituent of tooth enamel Cellular component • extracellular matrix • proteinaceous extracellular matrix • extracellular region Biological process • multicellular organism development • biomineral tissue development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	266	11704
Ensembl	ENSG00000099721	ENSMUSG00000031354
UniProt	Q99218	P63277
RefSeq (mRNA)	NM_001143	NM_001081978 NM_009666 NM_001290371
RefSeq (protein)	NP_001134.1	NP_001075447.1 NP_001277300.1 NP_033796.1
Location (UCSC)	Chr Y: 6.87 – 6.87 Mb	Chr X: 169.18 – 169.19 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Amelogenin, Y isoform is a protein that in humans is encoded by the AMELY (amelogenin, Y-linked) gene.^[3][4]

AMELY is a gene which encodes a form of amelogenin found on the Y chromosome. Amelogenin is a member of a family of extracellular matrix proteins. They are involved in biomineralization during tooth enamel development. Mutations in the related AMELX gene on the X chromosome cause X-linked amelogenesis imperfecta.^[4]

See also

• Amelogenin
• Y chromosome
• AMELX
• Amely (band)

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Nakahori Y, Takenaka O, Nakagome Y (February 1991). "A human X-Y homologous region encodes "amelogenin"". Genomics. 9 (2): 264–9. doi:10.1016/0888-7543(91)90251-9. PMID 2004775.
4. "Entrez Gene: amelogenin".

Further reading

• Nakahori Y, Tamura T, Nagafuchi S, et al. (1991). "Molecular cloning and mapping of 10 new probes on the human Y chromosome.". Genomics. 9 (4): 765–9. doi:10.1016/0888-7543(91)90373-M. PMID 2037302.
• Lau EC, Mohandas TK, Shapiro LJ, et al. (1989). "Human and mouse amelogenin gene loci are on the sex chromosomes.". Genomics. 4 (2): 162–8. doi:10.1016/0888-7543(89)90295-4. PMID 2737677.
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.". Nature. 423 (6942): 825–37. doi:10.1038/nature01722. PMID 12815422.
• Jobling MA, Lo IC, Turner DJ, et al. (2007). "Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y". Hum. Mol. Genet. 16 (3): 307–16. doi:10.1093/hmg/ddl465. PMC 2590852. PMID 17189292.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Salido EC, Yen PH, Koprivnikar K, et al. (1992). "The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes". Am. J. Hum. Genet. 50 (2): 303–16. PMC 1682460. PMID 1734713.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen AP, Chen Y, Wang HP, et al. (2007). "[Types and frequencies of variants in Amelogenin gene in Chinese population]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 24 (6): 615–9. PMID 18067069.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
• Yong RY, Gan LS, Chang YM, Yap EP (2007). "Molecular characterization of a polymorphic 3-Mb deletion at chromosome Yp11.2 containing the AMELY locus in Singapore and Malaysia populations". Hum. Genet. 122 (3–4): 237–49. doi:10.1007/s00439-007-0389-0. PMID 17588179.