ARID5B

ARID5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IG6, 2OEH
Identifiers
Aliases	ARID5B, DESRT, MRF-2, MRF2, AT-rich interaction domain 5B
External IDs	MGI: 2175912 HomoloGene: 45872 GeneCards: ARID5B
Genetically Related Diseases
rheumatoid arthritis, acute lymphocytic leukemia, lymphoblastic leukemia[1]
Gene ontology Molecular function • DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription coactivator activity • protein binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription regulatory region DNA binding • histone demethylase activity Cellular component • nucleoplasm • nucleus Biological process • fibroblast migration • fat pad development • palate development • male gonad development • regulation of transcription, DNA-templated • muscle organ morphogenesis • cell development • kidney development • multicellular organism growth • skeletal system morphogenesis • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of transcription from RNA polymerase II promoter • post-embryonic development • adrenal gland development • transcription, DNA-templated • female gonad development • nitrogen compound metabolic process • liver development • platelet-derived growth factor receptor signaling pathway • adipose tissue development • negative regulation of transcription, DNA-templated • fat cell differentiation • face morphogenesis • histone demethylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84159	71371
Ensembl	ENSG00000150347	ENSMUSG00000019947
UniProt	Q14865	Q8BM75
RefSeq (mRNA)	NM_001244638 NM_032199	NM_023598
RefSeq (protein)	NP_001231567.1 NP_115575.1	NP_076087.2
Location (UCSC)	Chr 10: 61.9 – 62.1 Mb	Chr 10: 68.1 – 68.28 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

AT-rich interactive domain-containing protein 5B is a protein that in humans is encoded by the ARID5B gene.^[4][5][6]

Alternative names for this gene include Modulator recognition factor 23.

Genomics

The gene is located on the long arm of chromosome 10 (10q21.2) on the Watson (plus) strand. It spans 195,261 base pairs in length. It encodes a protein of predicted length and molecular weight of 1188 amino acids and 132.375 kilo Daltons respectively.

Clinical importance

This gene has been associated with childhood leukaemia.

References

1. "Diseases that are genetically associated with ARID5B view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Lahoud MH, Ristevski S, Venter DJ, Jermiin LS, Bertoncello I, Zavarsek S, Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I (Aug 2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs". Genome Research. 11 (8): 1327–34. doi:10.1101/gr.168801. PMID 11483573.
5. Zhu L, Hu J, Lin D, Whitson R, Itakura K, Chen Y (Aug 2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA". Biochemistry. 40 (31): 9142–50. doi:10.1021/bi010476a. PMID 11478881.
6. "Entrez Gene: ARID5B AT rich interactive domain 5B (MRF1-like)".

Further reading

• Yuan YC, Whitson RH, Liu Q, Itakura K, Chen Y (Nov 1998). "A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases". Nature Structural Biology. 5 (11): 959–64. doi:10.1038/2934. PMID 9808040.
• Whitson RH, Huang T, Itakura K (May 1999). "The novel Mrf-2 DNA-binding domain recognizes a five-base core sequence through major and minor-groove contacts". Biochemical and Biophysical Research Communications. 258 (2): 326–31. doi:10.1006/bbrc.1999.0643. PMID 10329386.
• Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins". Nucleic Acids Research. 33 (1): 66–80. doi:10.1093/nar/gki145. PMC 546134. PMID 15640446.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.