Alexander van Oudenaarden

Alexander van Oudenaarden
Born (1970-03-19) 19 March 1970
Zuidland, The Netherlands
Residence The Netherlands
Citizenship Kingdom of The Netherlands
Fields Biophysics, Systems biology, Synthetic biology
Institutions Hubrecht Institute
Alma mater Delft University of Technology (M.S.,M.S.,Ph.D.)

Alexander van Oudenaarden (19 March 1970) is a Dutch biophysicist and systems biologist. He is a leading researcher in systems biology and synthetic biology, specialising in stochasticity in gene networks and actin dynamics. In 2012 he started as director of the Hubrecht Institute and was awarded an ERC Advanced Investigator award and NWO VICI award. In 2014 he became a member of the Royal Netherlands Academy of Arts and Sciences (KNAW).[1]

Biography

Alexander van Oudenaarden was born 19 March 1970, in Zuidland, a small town in the Dutch province of South Holland. He studied at the Delft University of Technology, where he obtained a Masters of Science in Materials Science and Engineering (cum laude) and a Masters of Science in Physics in 1993, and a Ph.D. in Physics (cum laude) in 1998 in experimental condensed matter physics, under the supervision of Prof. J.E. Mooij. He received the Andries Miedema Award (best Ph.D.-research in the field of condensed matter physics in the Netherlands) for his thesis on "Quantum vortices and quantum interference effects in circuits of small tunnel junctions". In 1998 he moved to Stanford, where he was a postdoctoral researcher in the departments of Biochemistry and of Microbiology & Immunology, working on force generation of polymerising actin filaments in the Theriot lab and a postdoctoral researcher in the department of Chemistry, working on Micropatterning of supported phospholipid bi-layers in the Boxer lab. In 2000 he joined the department of Physics at MIT as an assistant professor, was tenured in 2004 and is now a full professor. In 2001 he received the NSF CAREER award, and was both an Alfred Sloan Research Fellow and the Keck Career Development Career Development Professor in Biomedical Engineering. In 2012 Alexander became the director of the Hubrecht Institute as the successor of Hans Clevers.

He is married and has three children.

Work

During his time at MIT his lab started with parallel lines of research in actin dynamics[2][3] and noise in gene networks,[4][5][6] and then focused on stochasticity in gene networks[7][8][9][10] biological networks as control systems,[11][12][13] and the evolution of small networks.

Today, Van Oudenaardens work at the Hubrecht Institute focuses on stochastic gene expression,[14][15] developing new tools for quantifying gene expression in single cells [16][17] and MicroRNAs [18][19]

References

  1. ↑ "Alexander van Oudenaarden" (in Dutch). Royal Netherlands Academy of Arts and Sciences. Retrieved 1 July 2015.
  2. ↑ Upadhyaya, A; Chabot, J. R.; Andreeva, A.; Samadani, A.; van Oudenaarden, A. (2003). "Probing polymerization forces by using actin-propelled lipid vesicles". PNAS USA. 100 (8): 4521–6. Bibcode:2003PNAS..100.4521U. doi:10.1073/pnas.0837027100. PMC 153588Freely accessible. PMID 12657740.
  3. ↑ Upadhyaya, A; A. van Oudenaarden (2003). "Biomimetic systems for studying actin-based motility". Current Biology. 13 (18): R734. doi:10.1016/j.cub.2003.08.051. PMID 13678615.
  4. ↑ Thattai, M; A. van Oudenaarden (2001). "Intrinsic noise in gene regulatory networks". PNAS USA. 98 (15): 8614–9. Bibcode:2001PNAS...98.8614T. doi:10.1073/pnas.151588598. PMC 37484Freely accessible. PMID 11438714.
  5. ↑ Ozbudak, E.; Thattai, M.; Kurtser, I.; Grossman, A. D.; van Oudenaarden, A. (2002). "Regulation of noise in the expression of a single gene". Nature Genetics. 31 (1): 69–73. doi:10.1038/ng869. PMID 11967532.
  6. ↑ Thattai, M; A. van Oudenaarden (2002). "Attenuation of noise in ultrasensitive signaling cascades". Biophysical Journal. 82 (6): 2943–50. Bibcode:2002BpJ....82.2943T. doi:10.1016/S0006-3495(02)75635-X. PMC 1302082Freely accessible. PMID 12023217.
  7. ↑ Pedraza, J M; A. van Oudenaarden (2005). "Noise propagation in gene networks". Science. 307 (5717): 1965–9. Bibcode:2005Sci...307.1965P. doi:10.1126/science.1109090. PMID 15790857.
  8. ↑ Becskei, A; B. B. Kaufmann; A. van Oudenaarden (2005). "Contributions of low molecule number and chromosomal positioning to stochastic gene expression". Nature Genetics. 37 (9): 937–44. doi:10.1038/ng1616. PMID 16086016.
  9. ↑ Acar, M; A. Becskei; A. van Oudenaarden (2005). "Enhancement of cellular memory by reducing stochastic transitions". Nature. 435 (7039): 228–32. Bibcode:2005Natur.435..228A. doi:10.1038/nature03524. PMID 15889097.
  10. ↑ Chabot, J R; J. M. Pedraza; P. Luitel; A. van Oudenaarden (2007). "Stochastic gene expression out-of-steady-state in the cyanobacterial circadian clock". Nature. 450 (7173): 1249–52. Bibcode:2007Natur.450.1249C. doi:10.1038/nature06395. PMID 18097413.
  11. ↑ Thattai, M; A. Becskei; A. van Oudenaarden (2005). "A system of counteracting feedback loops regulates Cdc42p activity during spontaneous cell polarization". Developmental Cell. 9 (4): 565–71. doi:10.1016/j.devcel.2005.08.014. PMID 16198298.
  12. ↑ Tsang, J; J. Zhu; A. van Oudenaarden (2007). "MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals". Molecular Cell. 26 (5): 753–67. doi:10.1016/j.molcel.2007.05.018. PMC 2072999Freely accessible. PMID 17560377.
  13. ↑ Mettetal, J; D. Muzzey; C. Gomez-Uribe; A. van Oudenaarden (2008). "The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae". Science. 319 (5862): 482–4. Bibcode:2008Sci...319..482M. doi:10.1126/science.1151582. PMC 2916730Freely accessible. PMID 18218902.
  14. ↑ Junker, Philipp; Alexander. "Every cell is special: genome-wide studies add a new dimension to single-cell biology". Cell. 157: 8–11. doi:10.1016/j.cell.2014.02.010.
  15. ↑ Ji, Ni; Middelkoop, Teije; Mentink, Remco; Betist, Marco; Tonegawa, Satto; Mooijman, Dylan; Korswagen, Hendrik; Alexander (2013). "Feedback control of gene expression variability in the Caenorhabditis elegans Wnt pathway". Cell. 155: 869–880. doi:10.1016/j.cell.2013.09.060.
  16. ↑ Grün, Dominic; Kester, Lennart; Alexander (2014). "Validation of noise models for single-cell transcriptomics". Nature Methods. 11: 637–640. doi:10.1038/nmeth.2930.
  17. ↑ Klemm, Sandy; Semrau, Stefan; Wiebrands, Kay; Mooijman, Dylan; Faddah, Dina; Jaenisch, Rudolf; Alexander (2014). "Transcriptional profiling of cells sorted by RNA abundance". Nature Methods. 11: 549–551. doi:10.1038/nmeth.2910.
  18. ↑ Dong; Kim, Dominic Grün; Alexander (2013). "Dampening of expression oscillations by synchronous regulation of a microRNA and its target". Nature Genetics. 45: 1337–1344. doi:10.1038/ng.2763.
  19. ↑ Mukherji, Shankar; Ebert, Margaret; Zheng, Grace; Tsang, John; Sharp, Phil; Alexander (2011). "MicroRNAs can generate thresholds in target gene expression". Nature Genetics. 43: 854–859. doi:10.1038/ng.905.

External links

This article is issued from Wikipedia - version of the 9/26/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.