Anti-apoptotic Ras signalling cascade

The Anti-apoptotic Ras signaling cascade is an intracellular signal transduction cascade that involves the Ras protein and inhibits apoptosis. It is the target of the cancer drug gefitinib.

It may refer to the PI3K/AKT pathway.[1] [2] [3]

It may refer to the MAPK/ERK pathway which involves ras and can affect apoptosis.[4] [5]

The anti-apoptotic STAT pathway does not involve Ras.

References

  1. ↑ "Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways". 305 (5687). August 2004: 1163–7. doi:10.1126/science.1101637. PMID 15284455.
  2. ↑ http://genesdev.cshlp.org/content/11/6/701.abstract "The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal" 1997
  3. ↑ http://www.springerlink.com/content/86l52127046nx383/ 2Hypoinsulinemia Alleviates the Grf1/Ras/Akt Anti-Apoptotic Pathway and Induces Alterations of Mitochondrial Ras Trafficking in Neuronal Cells" 2009
  4. ↑ http://cancerres.aacrjournals.org/cgi/content/abstract/67/21/10343 "Suppression of PTEN Expression Is Essential for Antiapoptosis and Cellular Transformation by Oncogenic Ras" 2007
  5. ↑ http://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/972-b "Pathways potentiated by oncogenic Ras to modulate apoptosis induced by anticancer agent FR901228 " 2005

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