Archaeal transcription factor B

Archaeal transcription factor B (ATFB or TFB) (homologous to eukaryotic TFIIB) is a polypeptide important in archaeal transcription.

Structure

TFB is comprised an amino-terminal region (TFB_N) and a larger carboxyl-terminal region (TFB_C).

TFB_N is approximately one third of the protein and contains both a B-finger motif (homologous to the TFIIB B-finger) and a zinc-finger motif.

TFB_C is folded into a globulus which binds to the TATA binding protein (TBP) and to TFB-recognition elements (BRE) upstream of the TATA box. These bindings are important for transcription polarity.^[1]

See also

Archaeal transcription factor A
Archaeal RNA polymerase

References

↑ http://www.pnas.org/content/96/24/13662.full

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