Bronidox

Bronidox

Names
IUPAC name 5-Bromo-5-nitro-1,3-dioxane
Other names 5-Bromo-5-nitro-m-dioxane
Identifiers
CAS Number	30007-47-7
3D model (Jmol)	Interactive image
ChemSpider	1741
ECHA InfoCard	100.045.441
EC Number	250-001-7
PubChem	1807
UNII	U184I9QBNM
InChI InChI=1S/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2 Key: XVBRCOKDZVQYAY-UHFFFAOYSA-N InChI=1/C4H6BrNO4/c5-4(6(7)8)1-9-3-10-2-4/h1-3H2 Key: XVBRCOKDZVQYAY-UHFFFAOYAG
SMILES O=[N+]([O-])C1(Br)COCOC1
Properties
Chemical formula	C4H6BrNO4
Molar mass	212.00 g·mol^−1
Appearance	White crystalline powder
Melting point	60 °C (140 °F; 333 K)[1] 58.5−62 °C[2]
Solubility in water	insoluble
Hazards
Main hazards	Toxic
R-phrases	R22 R38
S-phrases	S36
Lethal dose or concentration (LD, LC):
LD50 (median dose)	590 mg/kg (mouse, oral) 455 mg/kg (rat, oral) 31 mg/kg (rat, ipr.) 2500 µg (mouse, skin) 2500 µg (rat, skin)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Bronidox, or 5-bromo-5-nitro-1,3-dioxane, is an antimicrobial chemical compound.

Bronidox causes inhibition of enzyme activity in bacteria.^[3]

Bronidox is corrosive to metals.^[4]

Uses

• Bactericide
• Fungicide, effective against yeast and other fungi
• It is used in immunology for preserving antibodies and antisera in 0.1 - 0.5% concentration. It is used as preservative to avoid use of sodium azide.
• Stabilizer
• Surfactant
• Used in cosmetics since the mid-1970s as preservative for shampoos, foam bath, etc. Maximum concentration is 0.1%.
• Some users do not recommend use in preparations destined for in vivo or tissue culture work^[5]

See also

• Bronopol

References

1. 5-BROMO-5-NITRO-1,3-DIOXANE, chemicalland21.com
2. "Archived copy" (PDF). Archived from the original (PDF) on September 29, 2007. Retrieved March 19, 2006.
3. Ghannoum M, Thomson M, Bowman W, Al-Khalil S (1986). "Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox)". Folia Microbiol. (Praha). 31 (1): 19–31. doi:10.1007/BF02928676. PMID 3082729.
4. http://www.products.cognis.com/COGNIS/prodleaf.nsf/(SBU_Catalog)/FFAD30C61B67EFEB41256B4100427DD1/$File/BRONIDOX_r_L_5_E.pdf
5. Archived December 21, 2004, at the Wayback Machine.