PDGFB

PDGFB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1PDG, 3MJG, 4HQU, 4HQX, 4QCI
Identifiers
Aliases	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, platelet derived growth factor subunit B
External IDs	MGI: 97528 HomoloGene: 74303 GeneCards: PDGFB
Gene ontology Molecular function • protein homodimerization activity • protein heterodimerization activity • chemoattractant activity • platelet-derived growth factor receptor binding • platelet-derived growth factor binding • superoxide-generating NADPH oxidase activator activity • growth factor activity • identical protein binding • collagen binding • protein binding • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • platelet alpha granule lumen • cytoplasm • extracellular region • Golgi membrane • basolateral plasma membrane • cell surface • endoplasmic reticulum lumen • membrane • extracellular fluid • extracellular matrix Biological process • activation of protein kinase B activity • positive regulation of DNA biosynthetic process • positive regulation of chemotaxis • cellular response to growth factor stimulus • positive regulation of protein tyrosine kinase activity • peptidyl-tyrosine phosphorylation • positive regulation of cell division • heart development • positive regulation of glomerular filtration • positive regulation of mitotic nuclear division • positive regulation of MAP kinase activity • positive regulation of metanephric mesenchymal cell migration • positive regulation of hyaluronan biosynthetic process • MAPK cascade • protein phosphorylation • positive regulation of glomerular mesangial cell proliferation • cellular response to mycophenolic acid • positive regulation of fibroblast proliferation • activation of protein kinase activity • multicellular organism development • positive regulation of protein autophosphorylation • positive regulation of reactive oxygen species metabolic process • reactive oxygen species metabolic process • negative regulation of transcription, DNA-templated • protein kinase C signaling • metanephric glomerular mesangial cell development • negative regulation of phosphatidylinositol biosynthetic process • response to wounding • positive regulation of phosphatidylinositol 3-kinase activity • cell chemotaxis • transforming growth factor beta receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • platelet degranulation • positive regulation of cell proliferation • positive regulation of DNA replication • positive regulation of gene expression • embryonic placenta development • paracrine signaling • monocyte chemotaxis • positive regulation of endothelial cell proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of calcium ion import • positive regulation of transcription, DNA-templated • peptidyl-serine phosphorylation • positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway • positive regulation of blood vessel endothelial cell migration • hemopoiesis • positive regulation of cell migration • phosphatidylinositol-mediated signaling • positive regulation of peptidyl-tyrosine phosphorylation • extracellular matrix organization • negative regulation of protein binding • positive regulation of MAPK cascade • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of platelet activation • phosphatidylinositol phosphorylation • positive regulation of vascular associated smooth muscle cell migration • positive chemotaxis • negative regulation of vascular smooth muscle cell differentiation • interleukin-18-mediated signaling pathway • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of gene expression • positive regulation of smooth muscle cell migration • positive regulation of smooth muscle cell proliferation • positive regulation of vascular smooth muscle cell dedifferentiation • positive regulation of GTPase activity • platelet-derived growth factor receptor signaling pathway • positive regulation of vascular smooth muscle cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5155	18591
Ensembl	ENSG00000100311	ENSMUSG00000000489
UniProt	P01127	P31240
RefSeq (mRNA)	NM_033016 NM_002608	NM_011057
RefSeq (protein)	NP_002599.1 NP_148937.1	NP_035187.2
Location (UCSC)	Chr 22: 39.22 – 39.24 Mb	Chr 15: 80 – 80.01 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene.^[3][4]

Function

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha (PDGFA) polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds.

Clinical significance

Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.^[5]

See also

• Platelet-derived growth factor

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Ratner L, Josephs SF, Jarrett R, Reitz MS, Wong-Staal F (Sep 1985). "Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor". Nucleic Acids Res. 13 (14): 5007–18. doi:10.1093/nar/13.14.5007. PMC 321845. PMID 2991848.
4. Clements JM, Bawden LJ, Bloxidge RE, Catlin G, Cook AL, Craig S, Drummond AH, Edwards RM, Fallon A, Green DR (Jan 1992). "Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation". EMBO J. 10 (13): 4113–20. PMC 453161. PMID 1661670.
5. "Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)".

Further reading

• Kurup S, Abramsson A, Li JP, Lindahl U, Kjellen L, Betsholtz C, Gerhardt H, Spillmann D (2006). "Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment". Biochem. Soc. Trans. 34 (Pt 3): 454–5. doi:10.1042/BST0340454. PMID 16709185.