CCL12

Ccl12
Identifiers
Aliases	chemokine (C-C motif) ligand 12MCP-5Scya12
External IDs	HomoloGene: 2245 GeneCards:
Gene ontology Molecular function • cytokine activity • CCR2 chemokine receptor binding • chemokine activity Cellular component • extracellular space • extracellular region • intracellular Biological process • negative regulation of neuron apoptotic process • G-protein coupled receptor signaling pathway • positive regulation of inflammatory response • protein kinase B signaling • monocyte chemotaxis • astrocyte cell migration • cytokine-mediated signaling pathway • chemokine-mediated signaling pathway • negative regulation of glial cell apoptotic process • cellular response to tumor necrosis factor • negative regulation of natural killer cell chemotaxis • cellular response to organic cyclic compound • neutrophil chemotaxis • MAPK cascade • chemotaxis • positive regulation of GTPase activity • positive regulation of calcium ion import • macrophage chemotaxis • cytoskeleton organization • angiogenesis • immune response • cellular response to interleukin-1 • positive regulation of ERK1 and ERK2 cascade • regulation of cell shape • cellular response to interferon-gamma • lymphocyte chemotaxis • inflammatory response • lipopolysaccharide-mediated signaling pathway • negative regulation of leukocyte proliferation • positive regulation of leukocyte migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	20293	6347
Ensembl	ENSMUSG00000035352	ENSG00000108691
UniProt	Q62401	P13500
RefSeq (mRNA)	NM_011331	NM_002982
RefSeq (protein)	NP_035461.2	NP_002973.1
Location (UCSC)	n/a	n/a
PubMed search	[1]	[2]
Wikidata

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Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attracts eosinophils, monocytes and lymphocytes.^[3] This chemokine is found predominantly in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages.^[3][4] It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J (1996). "Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation". J Exp Med. 184 (5): 1939–51. doi:10.1084/jem.184.5.1939. PMC 2192876. PMID 8920881.
4. Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A (1997). "Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1". J Exp Med. 185 (1): 99–109. doi:10.1084/jem.185.1.99. PMC 2196097. PMID 8996246.