CD69

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1E87, 1E8I, 1FM5, 3CCK, 3HUP

Identifiers

Aliases

CD69, AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3, CD69 molecule

External IDs

MGI: 88343 HomoloGene: 128584 GeneCards: CD69

Genetically Related Diseases

type 1 diabetes mellitus^[1]

Gene ontology
Molecular function	• calcium ion binding • protein binding • transmembrane signaling receptor activity • carbohydrate binding
Cellular component	• integral component of membrane • integral component of plasma membrane • membrane • external side of plasma membrane
Biological process	• cellular response to drug • signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


969


12515

Ensembl


ENSG00000110848


ENSMUSG00000030156

UniProt


Q07108


P37217

RefSeq (mRNA)


NM_001781


NM_001033122

RefSeq (protein)


NP_001772.1


NP_001028294.1

Location (UCSC)

Chr 12: 9.75 – 9.76 Mb

Chr 6: 129.27 – 129.28 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

CD69 (Cluster of Differentiation 69) is a human transmembrane C-Type lectin protein encoded by the CD69 gene.

The activation of T lymphocytes and Natural Killer (NK) Cells, both in vivo and in vitro, induces expression of CD69. This molecule, which appears to be the earliest inducible cell surface glycoprotein acquired during lymphoid activation, is involved in lymphocyte proliferation and functions as a signal-transmitting receptor in lymphocytes, including natural killer (NK) cells, and platelets (Cambiaggi et al., 1992) [supplied by OMIM].^[4]

References

Cambiaggi C, Scupoli MT, Cestari T, et al. (1992). "Constitutive expression of CD69 in interspecies T-cell hybrids and locus assignment to human chromosome 12.". Immunogenetics. 36 (2): 117–20. doi:10.1007/BF00215288. PMID 1612643.
López-Cabrera M, Muñoz E, Blázquez MV, et al. (1995). "Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements.". J. Biol. Chem. 270 (37): 21545–51. doi:10.1074/jbc.270.37.21545. PMID 7665567.
Bezouska K, Nepovím A, Horváth O, et al. (1995). "CD 69 antigen of human lymphocytes is a calcium-dependent carbohydrate-binding protein.". Biochem. Biophys. Res. Commun. 208 (1): 68–74. doi:10.1006/bbrc.1995.1306. PMID 7887967.
Santis AG, López-Cabrera M, Hamann J, et al. (1994). "Structure of the gene coding for the human early lymphocyte activation antigen CD69: a C-type lectin receptor evolutionarily related with the gene families of natural killer cell-specific receptors.". Eur. J. Immunol. 24 (7): 1692–7. doi:10.1002/eji.1830240735. PMID 8026529.
Ziegler SF, Ramsdell F, Hjerrild KA, et al. (1993). "Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens.". Eur. J. Immunol. 23 (7): 1643–8. doi:10.1002/eji.1830230737. PMID 8100776.
López-Cabrera M, Santis AG, Fernández-Ruiz E, et al. (1993). "Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal-transmitting receptors". J. Exp. Med. 178 (2): 537–47. doi:10.1084/jem.178.2.537. PMC 2191117. PMID 8340758.
Hamann J, Fiebig H, Strauss M (1993). "Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain". J. Immunol. 150 (11): 4920–7. PMID 8496594.
Krowka JF, Cuevas B, Maron DC, et al. (1996). "Expression of CD69 after in vitro stimulation: a rapid method for quantitating impaired lymphocyte responses in HIV-infected individuals". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 11 (1): 95–104. doi:10.1097/00042560-199601010-00013. PMID 8528739.
Iafrate AJ, Bronson S, Skowronski J (1997). "Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling". EMBO J. 16 (4): 673–84. doi:10.1093/emboj/16.4.673. PMC 1169669. PMID 9049297.
Vance BA, Bennett MJ, Ward Y, et al. (1999). "Distinct but dispensable N-glycosylation of human CD69 proteins". Arch. Biochem. Biophys. 368 (2): 214–20. doi:10.1006/abbi.1999.1322. PMID 10441371.
Blázquez MV, Macho A, Ortiz C, et al. (1999). "Extracellular HIV type 1 Tat protein induces CD69 expression through NF-kappaB activation: possible correlation with cell surface Tat-binding proteins". AIDS Res. Hum. Retroviruses. 15 (13): 1209–18. doi:10.1089/088922299310304. PMID 10480634.
Llera AS, Viedma F, Sánchez-Madrid F, Tormo J (2001). "Crystal structure of the C-type lectin-like domain from the human hematopoietic cell receptor CD69". J. Biol. Chem. 276 (10): 7312–9. doi:10.1074/jbc.M008573200. PMID 11036086.
Natarajan K, Sawicki MW, Margulies DH, Mariuzza RA (2001). "Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells". Biochemistry. 39 (48): 14779–86. doi:10.1021/bi0018180. PMID 11101293.
Liu X, Schrager JA, Lange GD, Marsh JW (2001). "HIV Nef-mediated cellular phenotypes are differentially expressed as a function of intracellular Nef concentrations". J. Biol. Chem. 276 (35): 32763–70. doi:10.1074/jbc.M101025200. PMID 11438519.
Diament D, Brunialti MK, Romero EC, et al. (2002). "Peripheral Blood Mononuclear Cell Activation Induced by Leptospira interrogans Glycolipoprotein". Infect. Immun. 70 (4): 1677–83. doi:10.1128/IAI.70.4.1677-1683.2002. PMC 127819. PMID 11895929.
Yoshimura C, Yamaguchi M, Iikura M, et al. (2002). "Activation markers of human basophils: CD69 expression is strongly and preferentially induced by IL-3". J. Allergy Clin. Immunol. 109 (5): 817–23. doi:10.1067/mai.2002.123532. PMID 11994706.
Pisegna S, Zingoni A, Pirozzi G, et al. (2002). "Src-dependent Syk activation controls CD69-mediated signaling and function on human NK cells". J. Immunol. 169 (1): 68–74. doi:10.4049/jimmunol.169.1.68. PMID 12077230.
Liu CC, Huang KJ, Lin YS, et al. (2002). "Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection". J. Med. Virol. 68 (2): 241–52. doi:10.1002/jmv.10198. PMID 12210415.
Foerster M, Haefner D, Kroegel C (2002). "Bcl-2-mediated regulation of CD69-induced apoptosis of human eosinophils: identification and characterization of a novel receptor-induced mechanism and relationship to CD95-transduced signalling". Scand. J. Immunol. 56 (4): 417–28. doi:10.1046/j.1365-3083.2002.01111.x. PMID 12234263.
Weigel G, Griesmacher A, Karimi A, et al. (2003). "Effect of mycophenolate mofetil therapy on lymphocyte activation in heart transplant recipients". J. Heart Lung Transplant. 21 (10): 1074–9. doi:10.1016/S1053-2498(02)00440-0. PMID 12398872.

PDB gallery

1e87: HUMAN CD69 - TRIGONAL FORM

1e8i: HUMAN CD69 - TETRAGONAL FORM

1fm5: CRYSTAL STRUCTURE OF HUMAN CD69

External links

CD69 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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CD69

See also

References

Further reading

External links