CDC40

CDC40
Identifiers
Aliases	CDC40, EHB3, PRP17, PRPF17, cell division cycle 40
External IDs	MGI: 1918963 HomoloGene: 5716 GeneCards: CDC40
Gene ontology Molecular function • second spliceosomal transesterification activity • poly(A) RNA binding • protein binding Cellular component • catalytic step 2 spliceosome • spliceosomal complex • nucleus • nucleoplasm Biological process • mRNA splicing, via spliceosome • termination of RNA polymerase II transcription • mRNA processing • generation of catalytic spliceosome for second transesterification step • mRNA export from nucleus • mRNA 3'-end processing • RNA splicing • RNA export from nucleus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51362	71713
Ensembl	ENSG00000168438	ENSMUSG00000038446
UniProt	O60508	Q9DC48
RefSeq (mRNA)	NM_015891	NM_027879
RefSeq (protein)	NP_056975.1	NP_082155.1
Location (UCSC)	Chr 6: 110.18 – 110.25 Mb	Chr 10: 40.83 – 40.88 Mb
PubMed search	[1]	[2]
Wikidata

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Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene.^[3][4][5]

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Ben Yehuda S, Dix I, Russell CS, Levy S, Beggs JD, Kupiec M (Oct 1998). "Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control". RNA. 4 (10): 1304–12. doi:10.1017/S1355838298980712. PMC 1369702. PMID 9769104.
4. Lindsey LA, Garcia-Blanco MA (Jan 1999). "Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p". J Biol Chem. 273 (49): 32771–5. doi:10.1074/jbc.273.49.32771. PMID 9830021.
5. "Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)".

Further reading

• Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. doi:10.1073/pnas.92.21.9530. PMC 40835. PMID 7568168.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhou Z, Reed R (1998). "Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing". EMBO J. 17 (7): 2095–106. doi:10.1093/emboj/17.7.2095. PMC 1170554. PMID 9524131.
• Ben-Yehuda S, Dix I, Russell CS, et al. (2001). "Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae". Genetics. 156 (4): 1503–17. PMC 1461362. PMID 11102353.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.