CFLAR

CFLAR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3H11, 3H13, 2N5R
Identifiers
Aliases	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator
External IDs	MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR
Gene ontology Molecular function • death receptor binding • cysteine-type peptidase activity • protein complex binding • protease binding • protein binding • cysteine-type endopeptidase activity involved in execution phase of apoptosis • enzyme activator activity • cysteine-type endopeptidase activity Cellular component • cytoplasm • cytosol • CD95 death-inducing signaling complex • ripoptosome • death-inducing signaling complex • membrane raft Biological process • regulation of apoptotic process • execution phase of apoptosis • negative regulation of extrinsic apoptotic signaling pathway • negative regulation of apoptotic process • proteolysis • skeletal myofibril assembly • skeletal muscle tissue regeneration • positive regulation of NF-kappaB transcription factor activity • negative regulation of myoblast fusion • skeletal muscle atrophy • positive regulation of I-kappaB kinase/NF-kappaB signaling • regulation of necroptotic process • regulation of extrinsic apoptotic signaling pathway via death domain receptors • viral process • regulation of skeletal muscle satellite cell proliferation • skeletal muscle tissue development • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • apoptotic process • positive regulation of catalytic activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8837	12633
Ensembl	ENSG00000003402	ENSMUSG00000026031
UniProt	O15519	O35732
RefSeq (mRNA)	NM_001127183 NM_001127184 NM_001202515 NM_001202516 NM_001202517 NM_001202518 NM_001202519 NM_001308042 NM_001308043 NM_003879	NM_001289704 NM_001293804 NM_001293805 NM_009805 NM_207653
RefSeq (protein)	NP_001120655.1 NP_001120656.1 NP_001189444.1 NP_001189445.1 NP_001189446.1 NP_001189447.1 NP_001189448.1 NP_001294971.1 NP_003870.4	NP_001276633.1 NP_997536.1
Location (UCSC)	Chr 2: 201.12 – 201.18 Mb	Chr 1: 58.71 – 58.76 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.^[3][4] Also called c-FLIP (FLICE-like inhibitory protein).

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.
4. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP". Nature. 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161.

Further reading

• Abe K, Kurakin A, Mohseni-Maybodi M, et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand.". Ann. N. Y. Acad. Sci. 926 (1): 52–63. doi:10.1111/j.1749-6632.2000.tb05598.x. PMID 11193041.
• Dutton A, Young LS, Murray PG (2006). "The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.". Expert Opin. Ther. Targets. 10 (1): 27–35. doi:10.1517/14728222.10.1.27. PMID 16441226.