CLASP2

CLASP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WOY
Identifiers
Aliases	CLASP2
External IDs	MGI: 1923749 HomoloGene: 24944 GeneCards: CLASP2
Gene ontology Molecular function • protein tyrosine kinase binding • dystroglycan binding • microtubule binding • microtubule plus-end binding • actin filament binding • protein binding Cellular component • cytoplasm • condensed chromosome kinetochore • cytosol • Golgi apparatus • cell projection • kinetochore microtubule • membrane • focal adhesion • plasma membrane • axonal growth cone • spindle • microtubule organizing center • chromosome • ruffle membrane • trans-Golgi network • cell cortex • cell leading edge • cortical microtubule plus-end • cytoplasmic microtubule • mitotic spindle • basal cortex • microtubule • chromosome, centromeric region • cytoskeleton • kinetochore Biological process • vesicle targeting • mitotic nuclear division • regulation of actin cytoskeleton organization • regulation of axon extension • Golgi organization • mitotic spindle organization • regulation of epithelial to mesenchymal transition • positive regulation of epithelial cell migration • exit from mitosis • cell division • establishment or maintenance of cell polarity • positive regulation of extracellular matrix disassembly • positive regulation of basement membrane assembly involved in embryonic body morphogenesis • negative regulation of microtubule depolymerization • microtubule anchoring • regulation of microtubule-based process • regulation of microtubule polymerization • regulation of microtubule polymerization or depolymerization • negative regulation of wound healing, spreading of epidermal cells • cell cycle • positive regulation of exocytosis • negative regulation of stress fiber assembly • microtubule organizing center organization • negative regulation of focal adhesion assembly • regulation of gastrulation • microtubule cytoskeleton organization • establishment of protein localization to plasma membrane • microtubule nucleation • platelet-derived growth factor receptor-beta signaling pathway • sister chromatid cohesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23122	76499
Ensembl	ENSG00000163539	ENSMUSG00000033392
UniProt	O75122	Q8BRT1
RefSeq (mRNA)	NM_001207044 NM_015097	NM_001081960 NM_001114347 NM_001286599 NM_001286600 NM_001286601 NM_001286602 NM_001286603 NM_029633
RefSeq (protein)	NP_001193973.1 NP_055912.2	NP_001273528.1 NP_001273529.1 NP_001273530.1 NP_001273531.1 NP_001273532.1
Location (UCSC)	Chr 3: 33.5 – 33.72 Mb	Chr 9: 113.81 – 113.92 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Cytoplasmic linker associated protein 2, also known as CLASP2, is a protein which in humans is encoded by the CLASP2 gene.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: CLASP2 cytoplasmic linker associated protein 2".

Further reading

• Galjart N (2005). "CLIPs and CLASPs and cellular dynamics.". Nat. Rev. Mol. Cell Biol. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712.
• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Lemos CL, Sampaio P, Maiato H, et al. (2000). "Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.". EMBO J. 19 (14): 3668–82. doi:10.1093/emboj/19.14.3668. PMC 313969. PMID 10899121.
• Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.". Cell. 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Maiato H, Fairley EA, Rieder CL, et al. (2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics.". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. PMID 12837247.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lee H, Engel U, Rusch J, et al. (2004). "The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance.". Neuron. 42 (6): 913–26. doi:10.1016/j.neuron.2004.05.020. PMID 15207236.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
• Wittmann T, Waterman-Storer CM (2005). "Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells.". J. Cell Biol. 169 (6): 929–39. doi:10.1083/jcb.200412114. PMC 2171640. PMID 15955847.
• Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.". Dev. Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
• Mimori-Kiyosue Y, Grigoriev I, Sasaki H, et al. (2006). "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.". Genes Cells. 11 (8): 845–57. doi:10.1111/j.1365-2443.2006.00990.x. PMID 16866869.
• Pereira AL, Pereira AJ, Maia AR, et al. (2007). "Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.". Mol. Biol. Cell. 17 (10): 4526–42. doi:10.1091/mbc.E06-07-0579. PMC 1635371. PMID 16914514.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.