COP9 signalosome complex subunit 3

COPS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D10, 4D18, 4WSN
Identifiers
Aliases	COPS3, CSN3, SGN3, COP9 signalosome subunit 3
External IDs	MGI: 1349409 HomoloGene: 2710 GeneCards: COPS3
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • COP9 signalosome • nucleus • nucleoplasm Biological process • transcription-coupled nucleotide-excision repair • in utero embryonic development • ubiquitin-dependent protein catabolic process • nucleotide-excision repair, DNA damage recognition • signal transduction • cullin deneddylation • response to light stimulus Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8533	26572
Ensembl	ENSG00000141030	ENSMUSG00000019373
UniProt	Q9UNS2	O88543
RefSeq (mRNA)	NM_001199125 NM_003653 NM_001316354 NM_001316355 NM_001316356 NM_001316357 NM_001316358	NM_011991
RefSeq (protein)	NP_001186054.1 NP_003644.2 NP_001303283.1 NP_001303284.1 NP_001303285.1 NP_001303286.1 NP_001303287.1	NP_036121.1
Location (UCSC)	Chr 17: 17.25 – 17.28 Mb	Chr 11: 59.82 – 59.84 Mb
PubMed search	[1]	[2]
Wikidata

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COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.^[3][4][5] It encodes a subunit of the COP9 signalosome.

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[5]

See also

• Signalosome

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. PMID 9535219.
4. Potocki L, Chen KS, Lupski JR (Jun 1999). "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2". Genomics. 57 (1): 180–2. doi:10.1006/geno.1998.5748. PMID 10191102.
5. "Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)".

Further reading

• Wolf DA, Zhou C, Wee S (2004). "The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?". Nat. Cell Biol. 5 (12): 1029–33. doi:10.1038/ncb1203-1029. PMID 14647295.
• van Dartel M, Hulsebos TJ (2004). "Amplification and overexpression of genes in 17p11.2 ~ p12 in osteosarcoma.". Cancer Genet. Cytogenet. 153 (1): 77–80. doi:10.1016/j.cancergencyto.2004.03.007. PMID 15325100.
• Wei N, Tsuge T, Serino G, et al. (1998). "The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex.". Curr. Biol. 8 (16): 919–22. doi:10.1016/S0960-9822(07)00372-7. PMID 9707402.
• Bianchi E, Denti S, Granata A, et al. (2000). "Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity.". Nature. 404 (6778): 617–21. doi:10.1038/35007098. PMID 10766246.
• Tsuge T, Matsui M, Wei N (2001). "The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.". J. Mol. Biol. 305 (1): 1–9. doi:10.1006/jmbi.2000.4288. PMID 11114242.
• Bech-Otschir D, Kraft R, Huang X, et al. (2001). "COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system". EMBO J. 20 (7): 1630–9. doi:10.1093/emboj/20.7.1630. PMC 145508. PMID 11285227.
• Lyapina S, Cope G, Shevchenko A, et al. (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
• Hong X, Xu L, Li X, et al. (2001). "CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation". FEBS Lett. 499 (1–2): 133–6. doi:10.1016/S0014-5793(01)02535-2. PMID 11418127.
• Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a Refined Smith-Magenis Syndrome Critical Deletion Interval on Chromosome 17p11.2 and the Syntenic Region of the Mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
• Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule". J. Cell. Sci. 116 (Pt 3): 453–61. doi:10.1242/jcs.00243. PMID 12508107.
• Serino G, Su H, Peng Z, et al. (2003). "Characterization of the Last Subunit of the Arabidopsis COP9 Signalosome: Implications for the Overall Structure and Origin of the Complex". Plant Cell. 15 (3): 719–31. doi:10.1105/tpc.009092. PMC 150025. PMID 12615944.
• Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
• Uhle S, Medalia O, Waldron R, et al. (2003). "Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome". EMBO J. 22 (6): 1302–12. doi:10.1093/emboj/cdg127. PMC 151059. PMID 12628923.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Groisman R, Polanowska J, Kuraoka I, et al. (2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–67. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143.
• Henriksen J, Aagesen TH, Maelandsmo GM, et al. (2003). "Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation". Oncogene. 22 (34): 5358–61. doi:10.1038/sj.onc.1206671. PMID 12917637.