COX8A

COX8A
Identifiers
Aliases	COX8A, COX, COX8, COX8-2, COX8L, VIII, VIII-L, cytochrome c oxidase subunit 8A
External IDs	MGI: 105959 HomoloGene: 3006 GeneCards: COX8A
Gene ontology Molecular function • cytochrome-c oxidase activity • protein binding Cellular component • integral component of membrane • mitochondrial inner membrane • mitochondrion • mitochondrial respiratory chain complex IV • membrane Biological process • generation of precursor metabolites and energy • xenophagy • positive regulation of defense response to virus by host • hydrogen ion transmembrane transport • mitochondrial electron transport, cytochrome c to oxygen Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1351	12868
Ensembl	ENSG00000176340	ENSMUSG00000035885
UniProt	P10176	Q64445
RefSeq (mRNA)	NM_004074	NM_007750
RefSeq (protein)	NP_004065.1	NP_031776.1
Location (UCSC)	Chr 11: 63.97 – 63.98 Mb	Chr 19: 7.22 – 7.22 Mb
PubMed search	[1]	[2]
Wikidata

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Cytochrome c oxidase subunit 8A is a protein that in humans is encoded by the COX8A gene.^[3] Cytochrome c oxidase 8A is a subunit of the cytochrome c oxidase complex, also known as Complex IV.

Structure

COX8A is a 7.6 kDa protein composed of 69 amino acids.^[4][5] This gene encodes the nuclear-encoded subunit 8A of the human mitochondrial respiratory chain enzyme complex cytochrome c oxidase. The complex consists of 13 mitochondrial- and nuclear-encoded subunits.^[3]

Function

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Cytochrome c oxidase subunit VIIIA (ubiquitous)".
4. Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
5. "Cytochrome c oxidase subunit 8A". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

External links

• Mass spectrometry characterization of COX8A at COPaKB

This article incorporates text from the United States National Library of Medicine, which is in the public domain.