Capping protein (actin filament) muscle Z-line, alpha 1

CAPZA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MQ1, 1MWN
Identifiers
Aliases	CAPZA1, CAPPA1, CAPZ, CAZ1, capping actin protein of muscle Z-line alpha subunit 1
External IDs	MGI: 106227 HomoloGene: 24376 GeneCards: CAPZA1
Gene ontology Molecular function • actin binding • protein binding • cadherin binding involved in cell-cell adhesion Cellular component • F-actin capping protein complex • cytoplasm • extracellular region • cytosol • WASH complex • extracellular exosome • cytoskeleton • actin cytoskeleton • cell-cell adherens junction Biological process • barbed-end actin filament capping • movement of cell or subcellular component • innate immune response • blood coagulation • actin filament capping • protein complex assembly • cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	829	12340
Ensembl	ENSG00000116489	ENSMUSG00000070372
UniProt	P52907	P47753
RefSeq (mRNA)	NM_006135	NM_009797
RefSeq (protein)	NP_006126.1	NP_033927.2
Location (UCSC)	Chr 1: 112.62 – 112.67 Mb	Chr 3: 104.82 – 104.86 Mb
PubMed search	[1]	[2]
Wikidata

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F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene.^[3][4][5]

CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein.

Function

The protein regulates growth of the actin filament by capping the barbed end (plus-end) of growing actin filaments, preventing any further assembly from occurring.^[5] This protein can be bound to the lipid PIP2 preventing it from binding to actin filaments.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Barron-Casella EA, Torres MA, Scherer SW, Heng HH, Tsui LC, Casella JF (Oct 1995). "Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families". J Biol Chem. 270 (37): 21472–9. doi:10.1074/jbc.270.37.21472. PMID 7665558.
4. Hart MC, Korshunova YO, Cooper JA (Apr 1997). "Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes". Genomics. 39 (3): 264–70. doi:10.1006/geno.1996.4506. PMID 9119363.
5. "Entrez Gene: CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1".

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Maun NA, Speicher DW, DiNubile MJ, Southwick FS (1996). "Purification and properties of a Ca(2+)-independent barbed-end actin filament capping protein, CapZ, from human polymorphonuclear leukocytes.". Biochemistry. 35 (11): 3518–24. doi:10.1021/bi952470p. PMID 8639502.
• Hart MC, Korshunova YO, Cooper JA (1997). "Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.". Cell Motil. Cytoskeleton. 38 (2): 120–32. doi:10.1002/(SICI)1097-0169(1997)38:2<120::AID-CM2>3.0.CO;2-B. PMID 9331217.
• Kuhlman PA, Fowler VM (1997). "Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducin.". Biochemistry. 36 (44): 13461–72. doi:10.1021/bi970601b. PMID 9354614.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Osterloh D, Ivanenkov VV, Gerke V (1999). "Hydrophobic residues in the C-terminal region of S100A1 are essential for target protein binding but not for dimerization.". Cell Calcium. 24 (2): 137–51. doi:10.1016/S0143-4160(98)90081-1. PMID 9803314.
• Inman KG, Yang R, Rustandi RR, et al. (2003). "Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12.". J. Mol. Biol. 324 (5): 1003–14. doi:10.1016/S0022-2836(02)01152-X. PMID 12470955.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• McClintock KA, Shaw GS (2003). "A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex.". J. Biol. Chem. 278 (8): 6251–7. doi:10.1074/jbc.M210622200. PMID 12480931.
• Taoka M, Ichimura T, Wakamiya-Tsuruta A, et al. (2003). "V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein.". J. Biol. Chem. 278 (8): 5864–70. doi:10.1074/jbc.M211509200. PMID 12488317.
• Hutchings NJ, Clarkson N, Chalkley R, et al. (2003). "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85.". J. Biol. Chem. 278 (25): 22396–403. doi:10.1074/jbc.M302540200. PMID 12690097.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.". Proteomics. 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Canton DA, Olsten ME, Niederstrasser H, et al. (2007). "The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein.". J. Biol. Chem. 281 (47): 36347–59. doi:10.1074/jbc.M607595200. PMC 2583070. PMID 16987810.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.