Carboxynorspermidine synthase
| Carboxynorspermidine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.5.1.43 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Carboxynorspermidine synthase (EC 1.5.1.43, carboxynorspermidine dehydrogenase, carboxyspermidine dehydrogenase, CASDH, CANSDH) is an enzyme with systematic name carboxynorspermidine:NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reactions
- (1) carboxynorspermidine + H2O + NADP+ L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H+
- (2) carboxyspermidine + H2O + NADP+ L-aspartate 4-semialdehyde + putrescine + NADPH + H+
The reaction takes place in the opposite direction.
References
- ↑ Nakao, H.; Shinoda, S.; Yamamoto, S. (1991). "Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus". J. Gen. Microbiol. 137 (7): 1737–1742. doi:10.1099/00221287-137-7-1737. PMID 1955861.
- ↑ Lee, J.; Sperandio, V.; Frantz, D.E.; Longgood, J.; Camilli, A.; Phillips, M.A.; Michael, A.J. (2009). "An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae". J. Biol. Chem. 284: 9899–9907. doi:10.1074/jbc.M900110200. PMC 2665113
. PMID 19196710. - ↑ Hanfrey, C.C.; Pearson, B.M.; Hazeldine, S.; Lee, J.; Gaskin, D.J.; Woster, P.M.; Phillips, M.A.; Michael, A.J. (2011). "Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota". J. Biol. Chem. 286: 43301–43312. doi:10.1074/jbc.M111.307835. PMC 3234850. PMID 22025614.
External links
- Carboxynorspermidine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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