Cytoplasm-to-vacuole targeting

Cytoplasm-to-vacuole targeting (Cvt) is an autophagy-related pathway in yeast. Under vegetative conditions it delivers hydrolases, such as aminopeptidase 1 (Ape1), to the vacuole.[1][2] This makes the cvt pathway the only known biosynthetic pathway to utilize the machinery of autophagy for operation.[1]

Nomenclature

The abbreviation Cvt comes from the emphasis Cytoplasm vacuole targeting, not from Cytoplasm-to-vacuole targeting.

References

  1. 1 2 Lynch-Day MA, Klionsky DJ (2010). "The Cvt pathway as a model for selective autophagy". FEBS Letters. 584 (7): 1359–66. doi:10.1016/j.febslet.2010.02.013. PMC 2843786Freely accessible. PMID 20146925.
  2. ↑ "The molecular machinery of autophagy: unanswered questions". Journal of Cell Science.


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