DCP1B

DCP1B
Identifiers
Aliases	DCP1B, DCP1, hDcp1b, decapping mRNA 1B
External IDs	MGI: 2442404 HomoloGene: 51881 GeneCards: DCP1B
Genetically Related Diseases
obesity[1]
Gene ontology Molecular function • enzyme regulator activity • enzyme activator activity • protein binding • mRNA binding • hydrolase activity Cellular component • cytoplasm • cytosol • cytoplasmic mRNA processing body • membrane • intracellular membrane-bounded organelle • nucleus Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • positive regulation of catalytic activity • deadenylation-independent decapping of nuclear-transcribed mRNA • deadenylation-dependent decapping of nuclear-transcribed mRNA • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	196513	319618
Ensembl	ENSG00000151065	ENSMUSG00000041477
UniProt	Q8IZD4	Q3U564
RefSeq (mRNA)	NM_152640 NM_001319292	NM_001033379
RefSeq (protein)	NP_689853.3	XP_011239675.1
Location (UCSC)	Chr 12: 1.95 – 2 Mb	Chr 6: 119.18 – 119.22 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene.^[4][5][6]

DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002).[supplied by OMIM]^[6]

References

1. "Diseases that are genetically associated with DCP1B view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
5. Cougot N, Babajko S, Seraphin B (Apr 2004). "Cytoplasmic foci are sites of mRNA decay in human cells". J Cell Biol. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023.
6. "Entrez Gene: DCP1B DCP1 decapping enzyme homolog B (S. cerevisiae)".

Further reading

• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.