DNAH9

DNAH9
Identifiers
Aliases	DNAH9, DNAH17L, DNEL1, DYH9, Dnahc9, HL-20, HL20, dynein axonemal heavy chain 9
External IDs	MGI: 1289279 HomoloGene: 20357 GeneCards: DNAH9
Genetically Related Diseases
myopia[1]
Gene ontology Molecular function • microtubule motor activity • nucleotide binding • ATPase activity • ATP binding • motor activity Cellular component • cytoplasm • dynein complex • axoneme • cell projection • cilium • microtubule • cytoskeleton Biological process • microtubule-based movement • movement of cell or subcellular component • cell projection organization • spermatogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1770	237806
Ensembl	ENSG00000007174	ENSMUSG00000056752
UniProt	Q9NYC9	n/a
RefSeq (mRNA)	NM_001372 NM_004662	NM_001099633
RefSeq (protein)	NP_001363.2 NP_004653.2	n/a
Location (UCSC)	Chr 17: 11.6 – 11.97 Mb	Chr 11: 65.83 – 66.17 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Dynein heavy chain 9, axonemal is a protein that in humans is encoded by the DNAH9 gene.^[4][5][6]

This gene encodes the heavy chain subunit of axonemal dynein, a large multi-subunit molecular motor. Axonemal dynein attaches to microtubules and hydrolyzes ATP to mediate the movement of cilia and flagella. The gene expresses at least two transcript variants; additional variants have been described, but their full length nature has not been determined.^[6]

References

1. "Diseases that are genetically associated with DNAH9 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (Feb 1997). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.
5. Bartoloni L, Blouin JL, Maiti AK, Sainsbury A, Rossier C, Gehrig C, She JX, Marron MP, Lander ES, Meeks M, Chung E, Armengot M, Jorissen M, Scott HS, Delozier-Blanchet CD, Gardiner RM, Antonarakis SE (Mar 2001). "Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia". Genomics. 72 (1): 21–33. doi:10.1006/geno.2000.6462. PMID 11247663.
6. "Entrez Gene: DNAH9 dynein, axonemal, heavy chain 9".

Further reading

• Milisav I, Jones MH, Affara NA (1996). "Characterization of a novel human dynein-related gene that is specifically expressed in testis". Mamm. Genome. 7 (9): 667–72. doi:10.1007/s003359900202. PMID 8703119.
• Nagase T; Ishikawa K; Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Bartoloni L; Blouin J; Sainsbury AJ; et al. (1999). "Assignment of the human dynein heavy chain gene DNAH17L to human chromosome 17p12 by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet. 84 (3–4): 188–9. doi:10.1159/000015254. PMID 10393427.
• Reed W; Carson JL; Moats-Staats BM; et al. (2001). "Characterization of an axonemal dynein heavy chain expressed early in airway epithelial ciliogenesis". Am. J. Respir. Cell Mol. Biol. 23 (6): 734–41. doi:10.1165/ajrcmb.23.6.4045. PMID 11104725.
• Maiti AK; Mattéi MG; Jorissen M; et al. (2001). "Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes". Eur. J. Hum. Genet. 8 (12): 923–32. doi:10.1038/sj.ejhg.5200555. PMID 11175280.
• Carson JL; Reed W; Lucier T; et al. (2002). "Axonemal dynein expression in human fetal tracheal epithelium". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (3): L421–30. doi:10.1152/ajplung.00147.2001. PMID 11839535.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Horváth J; Fliegauf M; Olbrich H; et al. (2005). "Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients". Am. J. Respir. Cell Mol. Biol. 33 (1): 41–7. doi:10.1165/rcmb.2004-0335OC. PMID 15845866.