DTL (gene)

DTL
Identifiers
Aliases	DTL, CDT2, DCAF2, L2RAMP, denticleless E3 ubiquitin protein ligase homolog
External IDs	MGI: 1924093 HomoloGene: 32313 GeneCards: DTL
Gene ontology Molecular function • ubiquitin-protein transferase activity • protein binding Cellular component • cytoplasm • centrosome • nuclear membrane • intracellular membrane-bounded organelle • membrane • nucleoplasm • chromosome • microtubule organizing center • nucleolus • Cul4A-RING E3 ubiquitin ligase complex • Cul4B-RING E3 ubiquitin ligase complex • cytoskeleton • nucleus Biological process • ubiquitin-dependent protein catabolic process • protein polyubiquitination • protein monoubiquitination • G2 DNA damage checkpoint • regulation of cell cycle • cellular response to DNA damage stimulus • DNA replication • protein ubiquitination • response to UV • DNA damage response, detection of DNA damage • translesion synthesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51514	76843
Ensembl	ENSG00000143476	ENSMUSG00000037474
UniProt	Q9NZJ0	Q3TLR7 P85176
RefSeq (mRNA)	NM_001286229 NM_001286230 NM_016448	NM_029766 NM_001305233
RefSeq (protein)	NP_001273158.1 NP_057532.3	NP_001292162.1 NP_084042.1
Location (UCSC)	Chr 1: 212.04 – 212.11 Mb	Chr 1: 191.54 – 191.58 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.^[3][4]

Interactions

DTL (gene) has been shown to interact with P21.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Cheung WM, Chu AH, Chu PW, Ip NY (May 2001). "Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation". J Biol Chem. 276 (20): 17083–91. doi:10.1074/jbc.M010802200. PMID 11278750.
4. "Entrez Gene: DTL denticleless homolog (Drosophila)".
5. Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (Sep 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes Dev. 22 (18): 2496–506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.

Further reading

• Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes.". Cell Cycle. 5 (15): 1719–29. doi:10.4161/cc.5.15.3150. PMID 16861890.
• Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H (2007). "L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.". Cell Cycle. 5 (15): 1675–80. doi:10.4161/cc.5.15.3149. PMID 16861906.
• Jin J, Arias EE, Chen J, Harper JW, Walter JC (2006). "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.". Mol. Cell. 23 (5): 709–21. doi:10.1016/j.molcel.2006.08.010. PMID 16949367.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H (2006). "CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.". Nat. Cell Biol. 8 (11): 1277–83. doi:10.1038/ncb1490. PMID 17041588.
• Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA (2006). "DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.". Genes Dev. 20 (22): 3117–29. doi:10.1101/gad.1482106. PMC 1635147. PMID 17085480.
• Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC (2007). "Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma.". Cell Cycle. 5 (22): 2676–87. doi:10.4161/cc.5.22.3500. PMID 17106265.