DYNC1I1

DYNC1I1
Identifiers
Aliases	DYNC1I1, dynein, cytoplasmic 1, intermediate chain 1, DNCI1, DNCIC1, dynein cytoplasmic 1 intermediate chain 1
External IDs	MGI: 107743 HomoloGene: 68398 GeneCards: DYNC1I1
Genetically Related Diseases
obesity, smallpox[1]
Gene ontology Molecular function • microtubule motor activity • spectrin binding • microtubule binding • protein binding • motor activity • dynein light chain binding Cellular component • cytoplasm • recycling endosome • condensed chromosome kinetochore • vesicle • cytosol • spindle pole • chromosome • cytoplasmic dynein complex • perinuclear region of cytoplasm • dynein complex • cytoplasmic ribonucleoprotein granule • microtubule • chromosome, centromeric region • cytoskeleton • nucleus • kinetochore Biological process • antigen processing and presentation of exogenous peptide antigen via MHC class II • vesicle transport along microtubule • ER to Golgi vesicle-mediated transport • microtubule-based movement • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1780	13426
Ensembl	ENSG00000158560	ENSMUSG00000029757
UniProt	O14576	O88485
RefSeq (mRNA)	NM_001135556 NM_001135557 NM_001278421 NM_001278422 NM_004411	NM_001191023 NM_001191025 NM_001191026 NM_001191027 NM_010063
RefSeq (protein)	NP_001129028.1 NP_001129029.1 NP_001265350.1 NP_001265351.1 NP_004402.1	NP_001177952.1 NP_001177954.1 NP_034193.2
Location (UCSC)	Chr 7: 95.77 – 96.11 Mb	Chr 6: 5.73 – 6.03 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.^[4][5][6]

In melanocytic cells DYNC1I1 gene expression may be regulated by MITF.^[7]

Interactions

DYNC1I1 has been shown to interact with DYNLL1.^[8]

References

1. "Diseases that are genetically associated with DYNC1I1 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics. 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID 10049579.
5. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
6. "Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1".
7. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
8. Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. United States. 41 (50): 14906–15. doi:10.1021/bi026417u. ISSN 0006-2960. PMID 12475239.

Further reading

• King SM, Dillman JF, Benashski SE, et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein.". J. Biol. Chem. 271 (50): 32281–7. doi:10.1074/jbc.271.50.32281. PMID 8943288.
• Lo KW, Naisbitt S, Fan JS, et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif.". J. Biol. Chem. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
• Horikawa I, Parker ES, Solomon GG, Barrett JC (2001). "Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells.". J. Cell. Biochem. 82 (3): 415–21. doi:10.1002/jcb.1169. PMID 11500918.
• Karki S, Ligon LA, DeSantis J, et al. (2002). "PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact.". Mol. Biol. Cell. 13 (5): 1722–34. doi:10.1091/mbc.02-02-0011. PMC 111139. PMID 12006665.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ligon LA, Tokito M, Finklestein JM, et al. (2004). "A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity.". J. Biol. Chem. 279 (18): 19201–8. doi:10.1074/jbc.M313472200. PMID 14985359.
• Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMC 419443. PMID 15121898.
• Chuang JZ, Yeh TY, Bollati F, et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth.". Dev. Cell. 9 (1): 75–86. doi:10.1016/j.devcel.2005.04.003. PMID 15992542.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.