David Spence
David Spence may refer to:
- David Spence (VC) (1818–1877), Scottish recipient of the Victoria Cross
- David Spence (Canadian politician) (1867–1940), former member of the Canadian House of Commons
- Dave Spence (born 1958), candidate for Governor in Missouri
- David Spence (Manitoba politician) (1824–1885), former politician in Manitoba, Canada
- David Allan Spence (1926–2003), New Zealand and British mathematician
- David Spence (rubber chemistry) (1881-1957), Pioneer in the field of rubber chemistry, and first recipient of the Charles Goodyear Medal.
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