EPS8L1

EPS8L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K2M, 2ROL
Identifiers
Aliases	EPS8L1, DRC3, EPS8R1, PP10566, EPS8 like 1
External IDs	MGI: 1914675 HomoloGene: 15767 GeneCards: EPS8L1
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • actin binding • T cell receptor binding • protein binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • ruffle membrane • extracellular exosome • protein complex • cell-cell adherens junction Biological process • regulation of Rho protein signal transduction • Rho protein signal transduction • positive regulation of ruffle assembly • positive regulation of GTPase activity • cell-cell adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	54869	67425
Ensembl	ENSG00000131037	ENSMUSG00000006154
UniProt	Q8TE68	Q8R5F8
RefSeq (mRNA)	NM_017729 NM_133180 NM_139204	NM_001290416 NM_026146
RefSeq (protein)	NP_060199.3 NP_573441.2	NP_001277345.1 NP_080422.1
Location (UCSC)	Chr 19: 55.07 – 55.09 Mb	Chr 7: 4.46 – 4.48 Mb
PubMed search	[1]	[2]
Wikidata

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Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.^[3][4]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
4. "Entrez Gene: EPS8L1 EPS8-like 1".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wu K, Xu Z, Wang M, et al. (1999). "[Cloning and expression analyses of down-regulated cDNA C6-2A in human esophageal cancer]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 16 (5): 325–7. PMID 10514543.