EPS8L2

EPS8L2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WWU, 1WXB
Identifiers
Aliases	EPS8L2, EPS8R2, EPS8 like 2
External IDs	MGI: 2138828 HomoloGene: 69358 GeneCards: EPS8L2
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • actin binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • ruffle membrane • vesicle • plasma membrane • extracellular exosome • protein complex • cell-cell adherens junction Biological process • regulation of Rho protein signal transduction • Rho protein signal transduction • positive regulation of ruffle assembly • cell-cell adhesion • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64787	98845
Ensembl	ENSG00000177106	ENSMUSG00000025504
UniProt	Q9H6S3	Q99K30
RefSeq (mRNA)	NM_022772	NM_133191
RefSeq (protein)	NP_073609.2	NP_573454.2
Location (UCSC)	Chr 11: 0.69 – 0.73 Mb	Chr 7: 141.34 – 141.36 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene.^[3][4]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
4. "Entrez Gene: EPS8L2 EPS8-like 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway.". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.