ERLIN1

ERLIN1
Identifiers
Aliases	ERLIN1, C10orf69, Erlin-1, KE04, KEO4, SPFH1, SPG62, ER lipid raft associated 1
External IDs	MGI: 2387613 HomoloGene: 4716 GeneCards: ERLIN1
Gene ontology Molecular function • cholesterol binding • protein binding • lipid binding • ubiquitin protein ligase binding Cellular component • integral component of membrane • membrane • protein complex • endoplasmic reticulum membrane • endoplasmic reticulum Biological process • SREBP signaling pathway • steroid metabolic process • cholesterol metabolic process • negative regulation of cholesterol biosynthetic process • negative regulation of fatty acid biosynthetic process • lipid metabolic process • ER-associated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10613	226144
Ensembl	ENSG00000107566	ENSMUSG00000025198
UniProt	O75477	Q91X78
RefSeq (mRNA)	NM_001100626 NM_006459	NM_001164359 NM_001164360 NM_145502
RefSeq (protein)	NP_001094096.1 NP_006450.2	NP_001157831.1 NP_001157832.1 NP_663477.3
Location (UCSC)	Chr 10: 100.15 – 100.19 Mb	Chr 19: 44.03 – 44.07 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Erlin-1 is a protein that in humans is encoded by the ERLIN1 gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Li N, Huang X, Zhao Z, Chen G, Zhang W, Cao X (Feb 2001). "Identification and characterization of a novel gene KE04 differentially expressed by activated human dendritic cells". Biochem Biophys Res Commun. 279 (2): 487–93. doi:10.1006/bbrc.2000.3935. PMID 11118313.
4. Browman DT, Resek ME, Zajchowski LD, Robbins SM (Jul 2006). "Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER". J Cell Sci. 119 (Pt 15): 3149–60. doi:10.1242/jcs.03060. PMID 16835267.
5. "Entrez Gene: ERLIN1 ER lipid raft associated 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.