ERVK6

ERVK-6
Identifiers
Aliases	ERVK-6, HERV-K(C7), HERV-K108, K-Rev, c-orf, cORF, ERVK-6, endogenous retrovirus group K member 6
External IDs	GeneCards: ERVK-6
EC number	3.4.23.50
Gene ontology Molecular function • peptidase activity • hydrolase activity • nucleic acid binding • aspartic-type endopeptidase activity • transferase activity • DNA binding • nuclease activity • endonuclease activity • nucleotidyltransferase activity • RNA-DNA hybrid ribonuclease activity • zinc ion binding • catalytic activity • metal ion binding • RNA-directed DNA polymerase activity • RNA binding • structural molecule activity Cellular component • cytoplasm • nucleolus • nucleus • viral capsid • plasma membrane • membrane • integral component of membrane • viral envelope • virion Biological process • proteolysis • RNA-dependent DNA biosynthetic process • DNA recombination • metabolic process • DNA integration • RNA phosphodiester bond hydrolysis, endonucleolytic • nucleic acid phosphodiester bond hydrolysis • mRNA transport • transport • viral process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64006	n/a
Ensembl	n/a	n/a
UniProt	Q9Y6I0 Q9BXR3 Q69383 Q7LDI9 Q69384 n/a	n/a
RefSeq (mRNA)	NM_001007236	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

HERV-K_19q12 provirus ancestral Pol protein is a protein that in humans is encoded by the ERVK6 gene.^[2][3][4]

References

1. "Human PubMed Reference:".
2. Mayer J, Sauter M, Racz A, Scherer D, Mueller-Lantzsch N, Meese E (Mar 1999). "An almost-intact human endogenous retrovirus K on human chromosome 7". Nat Genet. 21 (3): 257–8. doi:10.1038/6766. PMID 10080172.
3. Reus K, Mayer J, Sauter M, Scherer D, Muller-Lantzsch N, Meese E (Jun 2001). "Genomic organization of the human endogenous retrovirus HERV-K(HML-2.HOM) (ERVK6) on chromosome 7". Genomics. 72 (3): 314–20. doi:10.1006/geno.2000.6488. PMID 11401447.
4. "Entrez Gene: ERVK6 endogenous retroviral sequence K, 6".

Further reading

• Löwer R, Tönjes RR, Korbmacher C, et al. (1995). "Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K.". J. Virol. 69 (1): 141–9. PMC 188557. PMID 7983704.
• Sauter M, Schommer S, Kremmer E, et al. (1995). "Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.". J. Virol. 69 (1): 414–21. PMC 188589. PMID 7983737.
• Zsíros J, Jebbink MF, Lukashov VV, et al. (1998). "Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.". J. Gen. Virol. 79. ( Pt 1): 61–70. PMID 9460924.
• Andersson ML, Lindeskog M, Medstrand P, et al. (1999). "Diversity of human endogenous retrovirus class II-like sequences.". J. Gen. Virol. 80. ( Pt 1): 255–60. PMID 9934709.
• Berkhout B, Jebbink M, Zsíros J (1999). "Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.". J. Virol. 73 (3): 2365–75. PMC 104482. PMID 9971820.
• Barbulescu M, Turner G, Seaman MI, et al. (1999). "Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.". Curr. Biol. 9 (16): 861–8. doi:10.1016/S0960-9822(99)80390-X. PMID 10469592.
• Tönjes RR, Czauderna F, Kurth R (1999). "Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.". J. Virol. 73 (11): 9187–95. PMC 112952. PMID 10516026.
• Sugimoto J, Matsuura N, Kinjo Y, et al. (2001). "Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.". Genomics. 72 (2): 137–44. doi:10.1006/geno.2001.6473. PMID 11401426.
• Wang-Johanning F, Frost AR, Jian B, et al. (2003). "Quantitation of HERV-K env gene expression and splicing in human breast cancer.". Oncogene. 22 (10): 1528–35. doi:10.1038/sj.onc.1206241. PMID 12629516.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• de Parseval N, Lazar V, Casella JF, et al. (2003). "Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.". J. Virol. 77 (19): 10414–22. doi:10.1128/JVI.77.19.10414-10422.2003. PMC 228468. PMID 12970426.
• Blaise S, de Parseval N, Bénit L, Heidmann T (2004). "Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 13013–8. doi:10.1073/pnas.2132646100. PMC 240736. PMID 14557543.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
• Galli UM, Sauter M, Lecher B, et al. (2005). "Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors.". Oncogene. 24 (19): 3223–8. doi:10.1038/sj.onc.1208543. PMID 15735668.
• Mayer J, Stuhr T, Reus K, et al. (2006). "Haplotype analysis of the human endogenous retrovirus locus HERV-K(HML-2.HOM) and its evolutionary implications.". J. Mol. Evol. 61 (5): 706–15. doi:10.1007/s00239-005-0066-7. PMID 16211423.
• Romano CM, Ramalho RF, Zanotto PM (2006). "Tempo and mode of ERV-K evolution in human and chimpanzee genomes.". Arch. Virol. 151 (11): 2215–28. doi:10.1007/s00705-006-0792-1. PMID 16830071.