Enzastaurin

Enzastaurin
Names
IUPAC name
3-(1-Methylindol-3-yl)-4-[1-[1-(pyridin-2-ylmethyl)piperidin-4-yl]indol-3-yl]pyrrole-2,5-dione
Other names
LY-317615
Identifiers
170364-57-5 YesY
3D model (Jmol) Interactive image
ChEMBL ChEMBL300138 N
ChemSpider 153463 N
ECHA InfoCard 100.233.143
5693
PubChem 176167
UNII UC96G28EQF YesY
Properties
C32H29N5O2
Molar mass 515.62 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Enzastaurin is a synthetic bisindolylmaleimide with potential antineoplastic activity. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply, preventing growth.

In 2013 it failed a phase III clinical trial for lymphoma.[1]

References

This article is issued from Wikipedia - version of the 6/25/2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.