Examples of in vivo transdifferentiation by lineage-instructive approach

A list of examples of in vivo transdifferentiation through transfection:^[1]

• mouse hepatocytes → B cells (Pdx1)^[2]
• exocrine cells → B cells (Pdx1, Ngn3, and v-maf musculoaponeurotic fibrosarcoma oncogene family protein A)^[3]
• nonsensory cells → inner hair cells (Atoh1 and MathI)^[4]
• non cardiogenic mesoderm → cardiomyocytes (Gata4, Tbx5 and Smarcd3 or Baf60c)^[5]

Through excision:

• B-cell precursors → hematopoietic progenitors(-Pax5)^[6]
• In adult ovarian follicles, granulosa and thecal cells → functional Sertoli-like and Leydig-like cells (-Foxl1)^[7]

See also

• Transdifferentiation
• Induced stem cells

References

1. Pournasr, B.; Khaloughi, K.; Salekdeh, G. H.; Totonchi, M.; Shahbazi, E.; Baharvand, H. (2011). "Concise Review: Alchemy of Biology: Generating Desired Cell Types from Abundant and Accessible Cells". Stem Cells. 29 (12): 1933–1941. doi:10.1002/stem.760. PMID 21997905.
2. Ferber, S.; Halkin, A.; Cohen, H.; Ber, I.; Einav, Y.; Goldberg, I.; Barshack, I.; Seijffers, R.; Kopolovic, J.; Kaiser, N.; Karasik, A. (2000). "Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia". Nature Medicine. 6 (5): 568–572. doi:10.1038/75050. PMID 10802714.
3. Zhou, Q.; Brown, J.; Kanarek, A.; Rajagopal, J.; Melton, D. A. (2008). "In vivo reprogramming of adult pancreatic exocrine cells to β-cells". Nature. 455 (7213): 627–632. doi:10.1038/nature07314. PMID 18754011.
4. Izumikawa, M.; Minoda, R.; Kawamoto, K.; Abrashkin, K. A.; Swiderski, D. L.; Dolan, D. F.; Brough, D. E.; Raphael, Y. (2005). "Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals". Nature Medicine. 11 (3): 271–276. doi:10.1038/nm1193. PMID 15711559.
5. Takeuchi, J. K.; Bruneau, B. G. (2009). "Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors". Nature. 459 (7247): 708–711. doi:10.1038/nature08039. PMC 2728356. PMID 19396158.
6. Cobaleda, C. S.; Jochum, W.; Busslinger, M. (2007). "Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors". Nature. 449 (7161): 473–477. doi:10.1038/nature06159. PMID 17851532.
7. Uhlenhaut, N. H.; Jakob, S.; Anlag, K.; Eisenberger, T.; Sekido, R.; Kress, J.; Treier, A. C.; Klugmann, C.; Klasen, C.; Holter, N. I.; Riethmacher, D.; Schütz, G. N.; Cooney, A. J.; Lovell-Badge, R.; Treier, M. (2009). "Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation". Cell. 139 (6): 1130–1142. doi:10.1016/j.cell.2009.11.021. PMID 20005806.