FBXW10
| FBXW10 | ||||||
|---|---|---|---|---|---|---|
| Identifiers | ||||||
| Aliases | FBXW10, Fbw10, HREP, SM25H2, SM2SH2, F-box and WD repeat domain containing 10 | |||||
| External IDs | MGI: 3052463 HomoloGene: 32757 GeneCards: FBXW10 | |||||
| Orthologs | ||||||
| Species | Human | Mouse | ||||
| Entrez | ||||||
| Ensembl | ||||||
| UniProt | ||||||
| RefSeq (mRNA) | ||||||
| RefSeq (protein) |
| |||||
| Location (UCSC) | Chr 17: 18.74 – 18.78 Mb | Chr 11: 62.85 – 62.88 Mb | ||||
| PubMed search | [1] | [2] | ||||
| Wikidata | ||||||
| View/Edit Human | View/Edit Mouse |
F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene.[3][4][5]
Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).[supplied by OMIM][5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Kennerson ML, Nassif NT, Nicholson GA (Dec 1998). "Genomic structure and physical mapping of C17orf1: a gene associated with the proximal element of the CMT1A-REP binary repeat". Genomics. 53 (1): 110–2. doi:10.1006/geno.1998.5453. PMID 9787083.
- ↑ Kennerson ML, Gordon MJ, Blair IP, Nicholson GA (Dec 1995). "Single test for two hereditary neuropathies, CMT1A and HNPP". Clin Chem. 41 (10): 1534–5. PMID 7586531.
- 1 2 "Entrez Gene: FBXW10 F-box and WD repeat domain containing 10".
Further reading
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129
. PMID 16344560. - Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins.". Genes Dev. 18 (21): 2573–80. doi:10.1101/gad.1255304. PMC 525538. PMID 15520277.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
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