FM (chemotherapy)

FM in the context of chemotherapy means a chemotherapy regimen used as first-line therapy in indolent lymphomas. In combination with rituximab it is called R-FM or RFM or FM-R or FMR.

The [R]-FM regimen consists of:

1. (R)ituximab - an anti-CD20 monoclonal antibody that is able to kill both normal B cells and malignant ones;
2. (F)ludarabine - an antimetabolite;
3. (M)itoxantrone - a synthetic antracycline analogue (an antraquinone) that is able to intercalate DNA and prevent mitosis.^[1]

This regimen is also sometimes used in some autoimmune disorders that are inherently sensitive to rituximab, fludarabine and mitoxantrone in monotherapies (e.g. multiple sclerosis).

Dosing regimen

Drug	Dose	Mode	Days
(R)ituximab	375 mg/m^2	IV infusion	Day 1
(F)ludarabine	25 mg/m^2	IV infusion	Days 1-3
(M)itoxantrone	10 mg/m^2	IV infusion	Day 1

References

1. Fludarabine Plus Mitoxantrone With and Without Rituximab Versus CHOP With and Without Rituximab As Front-Line Treatment for Patients With Follicular Lymphoma