FREM1

FREM1
Identifiers
Aliases	FREM1, BNAR, C9orf143, C9orf145, C9orf154, MOTA, TILRR, TRIGNO2, FRAS1 related extracellular matrix 1
External IDs	MGI: 2670972 HomoloGene: 27049 GeneCards: FREM1
Gene ontology Molecular function • metal ion binding • carbohydrate binding Cellular component • integral component of membrane • extracellular region • basement membrane • proteinaceous extracellular matrix Biological process • multicellular organism development • cell communication • cell-matrix adhesion • cell adhesion • craniofacial suture morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	158326	329872
Ensembl	ENSG00000164946	ENSMUSG00000059049
UniProt	Q5H8C1	Q684R7
RefSeq (mRNA)	NM_001177704 NM_144966	NM_001198811 NM_177863
RefSeq (protein)	NP_001171175.1 NP_659403.4	NP_001185740.1 NP_808531.2
Location (UCSC)	Chr 9: 14.73 – 14.91 Mb	Chr 4: 82.9 – 83.05 Mb
PubMed search	[1]	[2]
Wikidata

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FRAS1-related extracellular matrix protein 1 is a protein that in humans is encoded by the FREM1 gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
4. Smyth I, Du X, Taylor MS, Justice MJ, Beutler B, Jackson IJ (Sep 2004). "The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis". Proc Natl Acad Sci U S A. 101 (37): 13560–5. doi:10.1073/pnas.0402760101. PMC 518794. PMID 15345741.
5. "Entrez Gene: FREM1 FRAS1 related extracellular matrix 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kiyozumi D, Osada A, Sugimoto N, et al. (2005). "Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle". Exp. Cell Res. 306 (1): 9–23. doi:10.1016/j.yexcr.2005.01.020. PMID 15878328.

External links

• GeneReviews/NCBI/NIH/UW entry on Manitoba Oculotrichoanal Syndrome, Marles Syndrome, MOTA Syndrome