Fibronectin type II domain

Fibronectin type II domain

Collagen-binding type II domain of seminal plasma protein PDC-109.[1]
Identifiers
Symbol fn2
Pfam PF00040
InterPro IPR000562
SMART SM00059
PROSITE PDOC00022
SCOP 1pdc
SUPERFAMILY 1pdc
OPM superfamily 123
OPM protein 1h8p
CDD cd00062

Fibronectin type II domain is a collagen-binding protein domain.

Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in an insoluble form in loose connective tissue and basement membranes, that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in a number of important functions e.g., wound healing; cell adhesion; blood coagulation; cell differentiation and migration; maintenance of the cellular cytoskeleton; and tumour metastasis.[2] The major part of the sequence of fibronectin consists of the repetition of three types of domains, which are called type I, II, and III.[3]

Type II domain is approximately sixty amino acids long,[4] contains four conserved cysteines involved in disulfide bonds and is part of the collagen-binding region of fibronectin. Type II domains occur two times in fibronectin. Type II domains have also been found in a range of proteins including blood coagulation factor XII; bovine seminal plasma proteins PDC-109 (BSP-A1/A2) and BSP-A3;[5] cation-independent mannose-6-phosphate receptor;[6] mannose receptor of macrophages;[7] 180 Kd secretory phospholipase A2 receptor;[8] DEC-205 receptor;[9] 72 Kd and 92 Kd type IV collagenase (EC 3.4.24.24);[10] and hepatocyte growth factor activator.[11]

Human proteins containing this domain

BSPH1; ELSPBP1; F12; FN1; HGFAC; IGF2R; LY75; MMP2; MMP9; MRC1; MRC1L1; MRC2; PLA2R1; SEL1L;

References

  1. Wah DA, Fernández-Tornero C, Sanz L, Romero A, Calvete JJ (April 2002). "Sperm coating mechanism from the 1.8 A crystal structure of PDC-109-phosphorylcholine complex". Structure. 10 (4): 505–14. doi:10.1016/S0969-2126(02)00751-7. PMID 11937055.
  2. Dean DC, Bowlus CL, Bourgeois S (1987). "Cloning and analysis of the promotor region of the human fibronectin gene". Proc. Natl. Acad. Sci. U.S.A. 84 (7): 1876–1880. doi:10.1073/pnas.84.7.1876. PMC 304544Freely accessible. PMID 3031656.
  3. Skorstengaard K, Jensen MS, Sahl P, Petersen TE, Magnusson S (1986). "Complete primary structure of bovine plasma fibronectin". Eur. J. Biochem. 161 (2): 441–453. doi:10.1111/j.1432-1033.1986.tb10464.x. PMID 3780752.
  4. Pankov R, Yamada KM (2002). "Fibronectin at a glance.". J Cell Sci. 115: 3861–3863. doi:10.1242/jcs.00059. PMID 12244123.
  5. Chretien M, Seidah NG, Manjunath P, Rochemont J, Sairam MR (1987). "Complete amino acid sequence of BSP-A3 from bovine seminal plasma. Homology to PDC-109 and to the collagen-binding domain of fibronectin". Biochem. J. 243 (1): 195–203. PMC 1147832Freely accessible. PMID 3606570.
  6. Kornfeld S (1992). "Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors". Annu. Rev. Biochem. 61 (1): 307–330. doi:10.1146/annurev.bi.61.070192.001515. PMID 1323236.
  7. Drickamer K, Taylor ME, Conary JT, Lennartz MR, Stahl PD (1990). "Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains". J. Biol. Chem. 265 (21): 12156–12162. PMID 2373685.
  8. Lazdunski M, Barhanin J, Lambeau G, Ancian P (1994). "Cloning and expression of a membrane receptor for secretory phospholipases A2". J. Biol. Chem. 269 (3): 1575–1578. PMID 8294398.
  9. Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, Nussenzweig MC (1995). "The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing". Nature. 375 (6527): 151–155. doi:10.1038/375151a0. PMID 7753172.
  10. Grant GA, Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Seltzer JL, Kronberger A, Bauer EA, Goldberg GI, He CS (1988). "H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen". J. Biol. Chem. 263 (14): 6579–6587. PMID 2834383.
  11. Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N (1993). "Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII". J. Biol. Chem. 268 (14): 10024–10028. PMID 7683665.

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