Formamidopyrimidine DNA glycosylase

Formamidopyrimidine DNA glycosylase (FPG) is a base excision repair enzyme which recognizes and removes a wide range of oxidized purines from correspondingly damaged DNA.[1] It was discovered by Zimbabwean scientist Christopher J. Chetsanga in 1975.[2]

References

  1. ↑ Serre1; Pereira De Jésus, K; Boiteux, S; Zelwer, C; Castaing, B; et al. (2002). "Crystal structure of the Lactococcus lactis formamidopyrimidine-DNA glycosylase bound to an abasic site analogue-containing DNA". The EMBO Journal. 21 (12): 2854–2865. doi:10.1093/emboj/cdf304. PMC 126059Freely accessible. PMID 12065399.
  2. ↑ Chetsanga, C.J.; Lindahl, T. (1979). "Release of 7-methylguanine residues whose imidazole rings have been opened from damaged DNA by a DNA glycosylase from Escherichia coli". Nucleic Acids Res 6 (11): 3673–84. doi:10.1093/nar/6.11.3673 . PMC 327965. PMID 386277.


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