GGPS1

GGPS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases GGPS1, GGPPS, GGPPS1, geranylgeranyl diphosphate synthase 1
External IDs MGI: 1341724 HomoloGene: 31267 GeneCards: GGPS1
EC number 2.5.1.1
Targeted by Drug
geranylgeranyl pyrophosphate, minodronic acid[1]
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

9453

14593

Ensembl

ENSG00000152904

ENSMUSG00000021302

UniProt

O95749

Q9WTN0

RefSeq (mRNA)

NM_001037277
NM_001037278
NM_004837

NM_010282

RefSeq (protein)

NP_001032354.1
NP_001032354.1

NP_034412.1

Location (UCSC) Chr 1: 235.33 – 235.34 Mb Chr 13: 14.05 – 14.06 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

Geranylgeranyl pyrophosphate synthetase is an enzyme that in humans is encoded by the GGPS1 gene.[4][5][6]

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

Much like its homolog farnesyl diphosphate synthase, GGPS1 is inhibited by bisphosphonate compounds.[7]

References

  1. "Drugs that physically interact with Geranylgeranyl pyrophosphate synthase view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Ericsson, J.; Greene, J.M.; Carter, K.C.; Shell, B.K.; Duan, D.R.; Florence, C.; Edwards, P.A. (December 1998). "Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression". Journal of Lipid Research. 39 (9): 1731–1739. PMID 9741684.
  5. Kainou, T.; Kawamura, K.; Tanaka, K.; Matsuda, H.; Kawamukai, M. (May 1999). "Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human". Biochimica et Biophysica Acta. 1437 (3): 333–340. doi:10.1016/S1388-1981(99)00028-1. PMID 10101267.
  6. 1 2 "Entrez Gene: GGPS1 geranylgeranyl diphosphate synthase 1".
  7. Wiemer, A.J.; Wiemer, D.F.; Hohl, R.J. (December 2011). "Geranylgeranyl diphosphate synthase: an emerging therapeutic target". Clinical Pharmacology and Therapeutics. 90 (6): 804–12. doi:10.1038/clpt.2011.215. PMID 22048229.

Further reading


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