GPM6A

GPM6A
Identifiers
Aliases	GPM6A, GPM6, M6A, glycoprotein M6A
External IDs	MGI: 107671 HomoloGene: 3864 GeneCards: GPM6A
Genetically Related Diseases
bipolar disorder[1]
Gene ontology Molecular function • calcium channel activity • protein binding Cellular component • integral component of membrane • extracellular vesicle • cell projection • membrane • filopodium • plasma membrane • dendritic spine • axonal growth cone • axon • neuronal cell body • neuron projection • extracellular exosome Biological process • neuron projection morphogenesis • neuron migration • stem cell differentiation • nervous system development • calcium ion transmembrane transport • synapse assembly • positive regulation of filopodium assembly • neural retina development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2823	234267
Ensembl	ENSG00000150625	ENSMUSG00000031517
UniProt	P51674	P35802
RefSeq (mRNA)	NM_001261447 NM_001261448 NM_005277 NM_201591 NM_201592	NM_001253754 NM_001253756 NM_153581
RefSeq (protein)	NP_001248377.1 NP_005268.1 NP_963885.1 NP_963886.1	NP_001240683.1 NP_001240685.1 NP_705809.1
Location (UCSC)	Chr 4: 175.63 – 176 Mb	Chr 8: 54.95 – 55.06 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Neuronal membrane glycoprotein M6-a is a protein that in humans is encoded by the GPM6A gene.^[4][5][6]

References

1. "Diseases that are genetically associated with GPM6A view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger SL, Yan Y, Lagenaur C, Narayanan V (Sep 1996). "Chromosomal mapping of the human M6 genes". Genomics. 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID 8661015.
5. Liang YJ, Wu DF, Stumm R, Hollt V, Koch T (Jul 2008). "Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway". Cell Res. 18 (7): 768–79. doi:10.1038/cr.2008.71. PMID 18574501.
6. "Entrez Gene: GPM6A glycoprotein M6A".

Further reading

• Boks MP, Hoogendoorn M, Jungerius BJ, et al. (2008). "Do mood symptoms subdivide the schizophrenia phenotype? association of the GMP6A gene with a depression subgroup". American Journal of Medical Genetics. 147b (6): 707–11. doi:10.1002/ajmg.b.30667. PMID 18163405.
• DeGiorgis JA, Jaffe H, Moreira JE, et al. (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. 4 (2): 306–15. doi:10.1021/pr0498436. PMID 15822905.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mukobata S, Hibino T, Sugiyama A, et al. (2002). "M6a acts as a nerve growth factor-gated Ca(2+) channel in neuronal differentiation". Biochem. Biophys. Res. Commun. 297 (4): 722–8. doi:10.1016/S0006-291X(02)02284-2. PMID 12359212.
• Shimizu F, Watanabe TK, Fujiwara T, et al. (1996). "Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33→q34". Cytogenet. Cell Genet. 74 (1–2): 138–9. doi:10.1159/000134401. PMID 8893821.
• Yan Y, Narayanan V, Lagenaur C (1996). "Expression of members of the proteolipid protein gene family in the developing murine central nervous system". J. Comp. Neurol. 370 (4): 465–78. doi:10.1002/(SICI)1096-9861(19960708)370:4<465::AID-CNE4>3.0.CO;2-2. PMID 8807448.