Gabriella Campadelli-Fiume

Gabriella Campadelli-Fiume
Residence	Italy
Fields	Microbiology, Virology
Institutions	University of Bologna
Education	Doctorate of Science, University of Bologna
Known for	Discovered triggers of receptor-bound gD activity Discovered that HSV utilizes gH/gL receptors, αvβ6- and αvβ8-intergins Discovered gD receptor, nectin1 to be HSV's receptor
Notable awards	Accademia Nazionale dei Lincei Pasteur Institute, Athens Fellowship in the American Academy of Microbiology

Gabriella Campadelli-Fiume is a virologist with a primary research focus on herpes simplex virus, fusion and viral entry.^[1] She is a retired professor of virology from the University of Bologna, located in Italy.^[1]

Education & Research

Gabriella Camapadelli-Fiume completed her Doctorate of Science (Sc.D) at the University of Bologna, Italy.^[2] Her specialization in virology was completed at the University of Bologna, as well.^[2] Campadelli-Fiume primarily researches Herpes Simplex Virus (HSV), particularly how HSV enters, assembles, and exits the cell during an active infection.^[2] In addition, she is interested in how HSV is induced to enter the exocytic pathway.^[2]

Primary Focus

Varicella-zoster Virus (5614251360)

• HSV entry into the cell ^[2]
• Viral assembly in cell ^[2]
• HSV exit out of the cell ^[2]
• Viral induced alteration of exocytic pathway ^[2]

Herpes Simplex Virus

Herpes Simplex Virus (HSV,herpes) consists of two types:

• Herpes simplex virus 1 (HSV-1)

*Transmitted by oral contact, causes orolabial herpes (cold sores) and genital herpes ^[3]

*HSV-1 is the most common infection through the world. It is a lifelong infection with no cure. However, treatment is available to minimize its symptoms

• Herpes simplex virus 2 (HSV-2)

*Sexually transmitted infection, can also cause genital herpes. HSV-2 has no cure, as well. It is a lifelong disease ^[3]

*Increased risk of acquiring HIV with HSV-2 ^[3]

BaltimoreVirusesClassification Classes I-VII (Legend: ss = single stranded; ds = double stranded)

Herpesviruses

Family	Herpesvirdae
Baltimore Classification	Group I
Genus Simplexvirus	Human Herpes simples virus type 1
Genus Subfamily	Alphaherpesvirinae

Major Discoveries

Campadelli-Fiume's discovery of nectin as the receptor for Herpes Simplex Virus (HSV), is one of her greatest accomplishments. Through her research, she also discovered the triggering activity of receptor- bound gD. In addition to these major discoveries, she uncovered the identity of the gF profusion domain, which provided the first evidence that retargeted HSVs exert anti-tumor activity.^[4]

Additional Contributions to Virology

Gabriella Campadelli-Fiume took part in a study published in the Journal of Virology published on August 5, 2009.^[5] The purpose of their research was to understand which glycoproteins were involved in the herpes simplex entry and fusion.^[5] Their findings indicated that the gD, gB, and gH/gL glycoproteins permit the herpes virus to enter the cell.^[5] Their research indicated that gD is not required for the interactions between the glycoproteins gB and gH/gL.^[5] Rather, their interactions are made possible due to the multiple sites carried by gB.^[5] The multiple sites of gB can be found in the pleckstrin-domain that carries the bipartite fusion loop, and interaction with gH/gL can take place successfully without gD.^[5]

A Woman of Influence

Women have made significant progress towards equality within scientific fields of work. However, as efforts to increase women's participation in science fields, inequality exists. Furthermore, an underrepresented group of women remain in these fields.^[6] Campadelli-Fiume is an influential woman who continues to bridge the gender gap within the scientific community. Her achievements throughout her career have earned substantial amounts of attention and credible recognition globally. As the author of an overall encyclopedic of basic virology and clinical manifestations, Human Herpesviruses,^[7] her work has been included in the University of Pennsylvania’s 2007 Celebration of Women Writers.^[8] She has gained recent attention for applaudable women in science by the International Society of Antiviral Research (ISAR) that has featured her as a prominent woman scientist.^[9] The American Academy of Microbiology awarded recognition of her scientific achievement and her contributions to advanced microbiology.^[10] Campadelli’s profound research, leadership principles, scientific achievements, and passion for virology, continue to convey a powerful impression to those within the scientific community. Her influence as a female scientist plays an important role to increasing the status of women in research.

Leadership

Gabriella Campadelli-Fiumme is an active member and leader in the scientific community.

Awards

• Accademia Nazionale dei Lincei ‘’2002’'^[2]
• Pasteur Institute, Athens ‘’1997’'^[2]
• Fellowship in the American Academy of Microbiology^[10]

Editorial Activity

• (2005–Present) Serves as an editorial board member for the Journal of Virology^[11]
• (2013–Present) Serves as an editorial board member for the Federation of European Microbiological Societies (FEMS) of Pathogens and Disease^[11]
• Serves on the International Advisory Board for The Lancet Journal^[11]

Scientific Society & Academy Founder

• European Society for Virology Founding Member & Executive Board Member^[11]
• European Academy of Microbiology Founding Member^[11]
• Italian Society of Virology Founding Member^[11]

Committee Service

• European Research Council^[11]
• DGXII Health Commissions^[11]
• Italian Ministry of Health

Member of Health Research Committee from 2000-2006'^[11]

Major Publications

Preclinical therapy of disseminated HER-2+ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus

Ichikawa K, Hughes IA, Horwitz AL, DeGroot LJ (1987). "Characterization of nuclear thyroid hormone receptors of cultured skin fibroblasts from patients with resistance to thyroid hormone". Metab. Clin. Exp. 36 (4): 392–9. doi:10.1016/0026-0495(87)90214-9. PMID 3561254.

Herpes Simplex Virus Glycoproteins gH/gL and gB Bind Toll-Like Receptor 2, and Soluble gH/gL Is Sufficient To Activate NF-κB

Singh GN, Gupta RP, Prakash P (1988). "Effect of ionic strength on the stability of norfloxacin". Pharmazie. 43 (2): 134. PMID 3393584.

AlphaV-beta3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts

Chong YH, Soh CC (1966). "The protein nutritive quality of ikan bilis (Stolephorus spp.)". Med J Malaya. 20 (3): 230–3. PMID 4223072.

Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain

"Butorphanol versus morphine: equally ineffective when given incorrectly". Ann Emerg Med. 18 (5): 603–5. 1989. doi:10.1016/s0196-0644(89)80869-8. PMID 2719377.

Construction of a Fully Retargeted Herpes Simplex Virus 1 Recombinant Capable of Entering Cells Solely via Human Epidermal Growth Factor Receptor 2

Zora JA, Lutz CN, Tinkelman DG (1989). "Assessment of compliance in children using inhaled beta adrenergic agonists". Ann Allergy. 62 (5): 406–9. PMID 2566291.

Herpes Simplex Virus gD Forms Distinct Complexes with Fusion Executors gB and gH/gL in Part through the C-terminal Profusion Domain

"Butorphanol versus morphine: equally ineffective when given incorrectly". Ann Emerg Med. 18 (5): 603–5. 1989. doi:10.1016/s0196-0644(89)80869-8. PMID 2719377.

Intracellular Trafficking and Maturation of Herpes Simplex Virus Type 1 gB and Virus Egress Require Functional Biogenesis of Multivesicular Bodies

Mihalik SJ, Rhead WJ (1991). "Species variation in organellar location and activity of L-pipecolic acid oxidation in mammals". J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. 160 (6): 671–6. doi:10.1007/bf00571266. PMID 2045546.

A Herpes Simplex Virus Recombinant That Exhibits a Single-Chain Antibody to HER2/neu Enters Cells through the Mammary Tumor Receptor, Independently of the gD Receptors

Ryan LM, Kurup IV, Derfus BA, Kushnaryov VM (1992). "ATP-induced chondrocalcinosis". Arthritis Rheum. 35 (12): 1520–5. doi:10.1002/art.1780351216. PMID 1472129.

Heptad Repeat 2 in Herpes Simplex Virus 1 gH Interacts with Heptad Repeat 1 and Is Critical for Virus Entry and Fusion

MacLeod SP, MacIntyre DR (1992). "Case report: calcification of genioglossus: a painful radiographic finding". Clin Radiol. 46 (2): 137–8. doi:10.1016/s0009-9260(05)80322-8. PMID 1395405.

Hydrophobic α-Helices 1 and 2 of Herpes Simplex Virus gH Interact with Lipids, and Their Mimetic Peptides Enhance Virus Infection and Fusion

Eberhardt KE, Thimm BM, Spring A, Maskos WR (1992). "Dose-dependent rate of nosocomial pulmonary infection in mechanically ventilated patients with brain oedema receiving barbiturates: a prospective case study". Infection. 20 (1): 12–8. doi:10.1007/bf01704886. PMID 1563806.

The Egress of Herpesviruses from Cells: the Unanswered Questions

De Castro Barbosa F, Agüera L, Rosell D, Isa W, Sánchez de la Muela P, Robles JE, Bergera JJ, Berián JM (1992). "[Retroperitoneal ganglioneuroma: an infrequent tumor]". Actas Urol Esp (in Spanish). 16 (9): 736–8. PMID 1488928.

The Ectodomain of Herpes Simplex Virus Glycoprotein H Contains a Membrane α-Helix with Attributes of an Internal Fusion Peptide, Positionally Conserved in the Herpesviridae Family

Menon PK, Rajagopalan PK (1979). "Seasonal changes in the density and natural mortality of immature stages of the urban malaria vector, Anopheles stephensi (Liston) in wells in Pondicherry". Indian J. Med. Res. 70 Suppl: 123–7. PMID 548475.

Coexpression of UL20p and gK Inhibits Cell-Cell Fusion Mediated by Herpes Simplex Virus Glycoproteins gD, gH-gL, and Wild-Type gB or an Endocytosis-Defective gB Mutant and Downmodulates Their Cell Surface Expression

Chen TR (1979). "Cytogenetics of somatic cell hybrids. I. Progression of stemlines in continuous uncloned cultures of man-mouse cell hybrids". Cytogenet. Cell Genet. 23 (4): 221–30. doi:10.1159/000131332. PMID 446093.

Entry of Herpes Simplex Virus Mediated by Chimeric Forms of Nectin1 Retargeted to Endosomes or to Lipid Rafts Occurs through Acidic Endosomes

Weimann S, Scharfetter H, Riedler L (1979). "[Esophageal tuberculosis]". Zentralbl Chir (in German). 104 (16): 1072–6. PMID 525084.

The Herpes Simplex Virus JMP Mutant Enters Receptor-Negative J Cells through a Novel Pathway Independent of the Known Receptors nectin1, HveA, and nectin2

Hussain S, Ehrenberg L (1979). "Mutagenicity of radiations at low doses". Hereditas. 91 (1): 111–5. doi:10.1111/j.1601-5223.1979.tb01649.x. PMID 387673.

References

1. "The way in of HSV: Routing by Integrins and Targeting to Cancer Receptors". Herpes Virus Workshop. Retrieved April 29, 2015. .
2. "Faculty Member's Website". Universita Di Bologna. Retrieved April 29, 2015.
3. "Herpes simplex virus". World Health Organization. Retrieved May 2015. Check date values in: |access-date= (help)
4. "GABRIELLA CAMPADELLI FIUME". American Society for Microbiology. Retrieved 19 May 2015.
5. Avitabile E, Forghieri C, Campadelli-Fiume G (2009). "Cross Talk among the Glycoproteins Involved in Herpes Simplex Virus Entry and Fusion: the Interaction between gB and gH/gL Does Not Necessarily Require gD". Journal of Virology. 83 (20): 10752–10760. doi:10.1128/JVI.01287-09.
6. "Women in STEM". The White House.
7. Arvin,Campadelli-Fiume, Mocarski, A., G., E. et al., (2007). Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University. Retrieved May 2015. Check date values in: |access-date= (help)
8. "WRITERS LIVING BETWEEN 2001 AND 2100". A Celebration of Women Writers. Retrieved May 2015. Check date values in: |access-date= (help)
9. "Women in Science 2015". International Society of Antiviral Research. Retrieved May 2015. Check date values in: |access-date= (help)
10. ses/2010-02/asfm-sse022310.php "78 scientists elected to the American Academy of Microbiology" Check |url= value (help). EurekAlert! The Global Source for Science News. Retrieved May 2015. Check date values in: |access-date= (help)
11. "Faculty Member Site". University of Bologna. Retrieved May 2015. Check date values in: |access-date= (help)