Guanine deaminase

GDA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AQL, 3E0L, 2UZ9
Identifiers
Aliases	GDA, guanine deaminase, CYPIN, GUANASE, NEDASIN, Guanine deaminase
External IDs	MGI: 95678 HomoloGene: 3171 GeneCards: GDA
Gene ontology Molecular function • guanine deaminase activity • zinc ion binding • hydrolase activity • metal ion binding Cellular component • cytosol • extracellular exosome • intracellular Biological process • guanine catabolic process • purine nucleotide catabolic process • nucleobase-containing compound metabolic process • guanine metabolic process • nervous system development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9615	14544
Ensembl	ENSG00000119125	ENSMUSG00000058624
UniProt	Q9Y2T3	Q9R111
RefSeq (mRNA)	NM_001242505 NM_001242506 NM_001242507 NM_004293	NM_010266
RefSeq (protein)	NP_001229434.1 NP_001229435.1 NP_001229436.1 NP_004284.1	NP_034396.1
Location (UCSC)	Chr 9: 72.11 – 72.26 Mb	Chr 19: 21.39 – 21.47 Mb
PubMed search	[1]	[2]
Wikidata

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Guanine deaminase also known as cypin, guanase, guanine aminase, GAH, and guanine aminohydrolase is an aminohydrolase enzyme which converts guanine to xanthine.^[3][4][5] Cypin is a major cytosolic protein that interacts with PSD-95. It promotes localized microtubule assembly in neuronal dendrites.^[6]

• 
  guanine
• 
  xanthine. Note nitrogen replaced with oxygen. (Ignore rotation.)

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Hitchings GH, Falco EA (Oct 1944). "The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase". Proceedings of the National Academy of Sciences of the United States of America. 30 (10): 294–7. doi:10.1073/pnas.30.10.294. PMC 1078714. PMID 16578130.
4. Kalckar HM (1947). "Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism". J. Biol. Chem. 167 (2): 461–75. PMID 20285041.
5. Rabinowitz JC, Barker HA (Jan 1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations". The Journal of Biological Chemistry. 218 (1): 161–73. PMID 13278325.
6. Firestein BL, Firestein BL, Brenman JE, Aoki C, Sanchez-Perez AM, El-Husseini AE, Bredt DS (1999). "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting". Neuron. 24 (3): 659–72. doi:10.1016/S0896-6273(00)81120-4. PMID 10595517.

External links

• Guanine deaminase at the US National Library of Medicine Medical Subject Headings (MeSH)