HLA-B50




major histocompatibility complex (human), class I, B50
Alleles	B5001, B5002,
Structure (See HLA-B)
Symbol(s)	HLA-B
EBI-HLA	B*5001
	B*5002
Locus	chr.6 6p21.31

HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49.^[1] The serotype identifies the more common HLA-B*50 gene products.^[2] (For terminology help see: HLA-serotype tutorial)

Serotype

B50 and B21 serotype recognition of some more common HLA B*50 alleles^[3]
B*50	B50	B21	Sample
allele	%	%	size (N)
5001	85	3	1700

The B*5002 by serotype definition is a B45 serotype.^[4]

Allele distribution

**HLA B*5001 frequencies**
		freq
ref.	Population	(%)
^[5]	Saudi Arabia Guraiat and Hail	17.3
^[5]	Tunisia	10.0
^[5]	Israel Arab Druse	8.5
^[5]	Morocco Nador Metalsa (Berber)	7.3
^[5]	Tunisia Tunis	6.3
^[5]	Israel Ashkenazi and Non Ashkenazi Jews	5.5
^[5]	Azores Terceira Island	5.1
^[5]	Georgia Svaneti Svans	3.8
^[5]	India North Delhi	3.8
^[5]	Italy Bergamo	3.6
^[5]	Georgia Tibilisi Kurds	3.4
^[5]	Italy North (1)	3.3
^[5]	Brazil Belo Horizonte	3.2
^[5]	Madeira	3.2
^[5]	Italy North Pavia	3.1
^[5]	Portugal South	3.1
^[5]	Oman	3.0
^[5]	Georgia Tibilisi Georgians	2.8
^[5]	Bulgaria	2.7
^[5]	Azores Santa Maria and Sao Miguel	2.6
^[5]	Spain Eastern Andalusia Gipsy	2.5
^[5]	Sudanese	2.5
^[5]	Czech Republic	2.4
^[5]	Spain Eastern Andalusia	2.4
^[5]	Spain Majorca and Minorca	2.2
^[5]	Burkina Faso Fulani	2.0
^[5]	China Inner Mongolia	2.0
^[5]	China North Han	1.9
^[5]	India North Hindus	1.9
^[5]	China Qinghai Hui	1.8
^[5]	Jordan Amman	1.7
^[5]	Russia Tuva (2)	1.7
^[5]	Spain Catalonia Girona	1.7
^[5]	Senegal Niokholo Mandenka	1.6
^[5]	Guinea Bissau	1.5
^[5]	India New Delhi	1.5
^[5]	Croatia	1.3
^[5]	Cuban Mulatto	1.2
^[5]	France South East	1.2
^[5]	Burkina Faso Rimaibe	1.1
^[5]	Mali Bandiagara	1.1
^[5]	Belgium	1.0
^[5]	Ireland Northern	1.0
^[5]	Ireland South	1.0
^[5]	Italy Sardinia pop3	1.0
^[5]	South Africa Natal Tamil	1.0
	*B5002**
^[5]	Morocco Nador Metalsa (Berber)	4.3
^[5]	Portugal North	1.1
^[5]	Portugal South	1.0
^[5]	Madeira	0.8
^[5]	Tunisia Tunis	0.6

References

↑ Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.
↑ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
↑ derived from IMGT/HLA
↑ Balas A, Santos S, García-Sánchez F, Lillo R, Merino L, Vicario JL (1998). "Characterization and distribution of HLA-B*5002 in a Spanish population sample". Tissue Antigens. 52 (2): 183–6. doi:10.1111/j.1399-0039.1998.tb02283.x. PMID 9756408.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)

HLA-B serotypes and allele groups

HLA-B B5 B51 B52 B7 B8 B12 B44 B45 B13 B14 B64 B65 B15 B62 B63 B70 B71 B72 B75 B76 B77 B16 B38 B39 B17 B57 B58 B18 B21 B49 B50 B22 B54 B55 B56 B27 B35 B37 B40 B60 B61 B41 B42 B46 B47 B48 B53 B59 B67 B73 B78 B81 B82 B83

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