HNRNPLL

HNRNPLL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WEX, 2E5I
Identifiers
Aliases	HNRNPLL, HNRPLL, SRRF, heterogeneous nuclear ribonucleoprotein L like
External IDs	MGI: 1919942 HomoloGene: 26701 GeneCards: HNRNPLL
Gene ontology Molecular function • nucleotide binding • poly(A) RNA binding • protein binding • mRNA binding • RNA binding • nucleic acid binding Cellular component • intracellular ribonucleoprotein complex • membrane • nucleus Biological process • positive regulation of RNA splicing • mRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	92906	72692
Ensembl	ENSG00000143889	ENSMUSG00000024095
UniProt	Q8WVV9	Q921F4
RefSeq (mRNA)	NM_001142650 NM_138394	NM_144802
RefSeq (protein)	NP_001136122.1 NP_612403.2	NP_659051.3
Location (UCSC)	Chr 2: 38.56 – 38.6 Mb	Chr 17: 80.03 – 80.06 Mb
PubMed search	[1]	[2]
Wikidata

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Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene. ^[3]

Function

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008].

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Heterogeneous nuclear ribonucleoprotein L-like". Retrieved 2014-01-24.

Further reading

• Lai, Y.; Song, M.; Hakala, K.; Weintraub, S. T.; Shiio, Y. (2011). "Proteomic Dissection of the von Hippel–Lindau (VHL) Interactome". Journal of Proteome Research. 10 (11): 5175–5182. doi:10.1021/pr200642c. PMC 3208728. PMID 21942715.
• Topp, J. D.; Jackson, J.; Melton, A. A.; Lynch, K. W. (2008). "A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4". RNA. 14 (10): 2038–2049. doi:10.1261/rna.1212008. PMC 2553740. PMID 18719244.
• Wu, Z.; Yates, A. L.; Hoyne, G. F.; Goodnow, C. C. (2010). "Consequences of Increased CD45RA and RC Isoforms for TCR Signaling and Peripheral T Cell Deficiency Resulting from Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation". The Journal of Immunology. 185 (1): 231–238. doi:10.4049/jimmunol.0903625. PMID 20505149.
• Oberdoerffer, S.; Moita, L. F.; Neems, D.; Freitas, R. P.; Hacohen, N.; Rao, A. (2008). "Regulation of CD45 Alternative Splicing by Heterogeneous Ribonucleoprotein, hnRNPLL". Science. 321 (5889): 686–691. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861.
• Fedorova, O. A.; Moiseeva, T. N.; Nikiforov, A. A.; Tsimokha, A. S.; Livinskaya, V. A.; Hodson, M.; Bottrill, A.; Evteeva, I. N.; Ermolayeva, J. B.; Kuznetzova, I. M.; Turoverov, K. K.; Eperon, I.; Barlev, N. A. (2011). "Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism". Biochemical and Biophysical Research Communications. 416 (3–4): 258–265. doi:10.1016/j.bbrc.2011.10.126. PMID 22079093.
• Shur, I.; Ben-Avraham, D.; Benayahu, D. (2004). "Alternatively spliced isoforms of a novel stromal RNA regulating factor". Gene. 334: 113–121. doi:10.1016/j.gene.2004.03.012. PMID 15256261.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.