INSL5

INSL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K1V, 2KBC
Identifiers
Aliases	INSL5, PRO182, UNQ156, insulin like 5
External IDs	MGI: 1346085 HomoloGene: 48350 GeneCards: INSL5
Gene ontology Molecular function • hormone activity • G-protein coupled receptor binding Cellular component • cellular component • extracellular region Biological process • biological process • positive regulation of feeding behavior Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10022	23919
Ensembl	ENSG00000172410	ENSMUSG00000066090
UniProt	Q9Y5Q6	Q9WUG6
RefSeq (mRNA)	NM_005478	NM_001290648 NM_011831
RefSeq (protein)	NP_005469.2	NP_001277577.1 NP_035961.1
Location (UCSC)	Chr 1: 66.8 – 66.8 Mb	Chr 4: 103.02 – 103.03 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Insulin-like peptide INSL5 is a protein that in humans is encoded by the INSL5 gene.^[3][4]

Function

The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7).^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Conklin D, Lofton-Day CE, Haldeman BA, Ching A, Whitmore TE, Lok S, Jaspers S (August 1999). "Identification of INSL5, a new member of the insulin superfamily". Genomics. 60 (1): 50–6. doi:10.1006/geno.1999.5899. PMID 10458910.
4. "Entrez Gene: INSL5 insulin-like 5".

Further reading

• Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J, Wilkinson T, Bathgate R, Eriste E, Sillard R, Lovenberg TW (January 2005). "INSL5 is a high affinity specific agonist for GPCR142 (GPR100)". The Journal of Biological Chemistry. 280 (1): 292–300. doi:10.1074/jbc.M409916200. PMID 15525639.
• Zhang Z, Henzel WJ (October 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Koman A, Cazaubon S, Couraud PO, Ullrich A, Strosberg AD (August 1996). "Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family". The Journal of Biological Chemistry. 271 (34): 20238–41. doi:10.1074/jbc.271.34.20238. PMID 8702754.

External links

• INSL5 human gene location in the UCSC Genome Browser.
• INSL5 human gene details in the UCSC Genome Browser.