INSRR

INSRR
Identifiers
Aliases	INSRR, IRR, insulin receptor related receptor
External IDs	MGI: 1346037 HomoloGene: 56539 GeneCards: INSRR
Gene ontology Molecular function • transmembrane receptor protein tyrosine kinase activity • phosphatidylinositol 3-kinase binding • insulin receptor substrate binding • nucleotide binding • protein kinase activity • protein tyrosine kinase activity • transferase activity • ATP binding • kinase activity Cellular component • receptor complex • integral component of membrane • integral component of plasma membrane • membrane Biological process • actin cytoskeleton reorganization • protein autophosphorylation • protein phosphorylation • cellular response to alkaline pH • male sex determination • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3645	23920
Ensembl	ENSG00000027644	ENSMUSG00000005640
UniProt	P14616	Q9WTL4
RefSeq (mRNA)	NM_014215	NM_011832
RefSeq (protein)	NP_055030.1	NP_035962.2
Location (UCSC)	Chr 1: 156.84 – 156.86 Mb	Chr 3: 87.8 – 87.82 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Shier P, Watt VM (Oct 1989). "Primary structure of a putative receptor for a ligand of the insulin family". J Biol Chem. 264 (25): 14605–8. PMID 2768234.
4. Shier P, Willard HF, Watt VM (Jan 1991). "Localization of the insulin receptor-related receptor gene to human chromosome 1". Cytogenet Cell Genet. 54 (1–2): 80–1. doi:10.1159/000132963. PMID 2249481.
5. "Entrez Gene: INSRR insulin receptor-related receptor".

Further reading

• Zhang B, Roth RA (1992). "The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities". J. Biol. Chem. 267 (26): 18320–8. PMID 1326521.
• Mathi SK, Chan J, Watt VM (1995). "Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney". Endocrinology. 136 (9): 4125–32. doi:10.1210/en.136.9.4125. PMID 7649121.
• Kovacina KS, Roth RA (1995). "Characterization of the endogenous insulin receptor-related receptor in neuroblastomas". J. Biol. Chem. 270 (4): 1881–7. doi:10.1074/jbc.270.4.1881. PMID 7829525.
• Jui HY, Accili D, Taylor SI (1996). "Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells". Biochemistry. 35 (45): 14326–30. doi:10.1021/bi9613032. PMID 8916919.
• Hänze J, Berthold A, Klammt J, et al. (1999). "Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor". Horm. Metab. Res. 31 (2–3): 77–9. doi:10.1055/s-2007-978702. PMID 10226785.
• Xu P, Jacobs AR, Taylor SI (1999). "Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins". J. Biol. Chem. 274 (21): 15262–70. doi:10.1074/jbc.274.21.15262. PMID 10329736.
• Elmlinger MW, Rauschnabel U, Koscielniak E, et al. (1999). "Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin". Regul. Pept. 84 (1–3): 37–42. doi:10.1016/S0167-0115(99)00065-8. PMID 10535406.
• Whitmore TE, Maurer MF, Day HL, et al. (2000). "The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21→q23 by the use of radiation hybrid mapping". Cytogenet. Cell Genet. 87 (1–2): 93–4. doi:10.1159/000015400. PMID 10640820.
• Weber A, Huesken C, Bergmann E, et al. (2004). "Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas". Clin. Cancer Res. 9 (15): 5683–92. PMID 14654552.
• Klammt J, Garten A, Barnikol-Oettler A, et al. (2005). "Comparative analysis of the signaling capabilities of the insulin receptor-related receptor". Biochem. Biophys. Res. Commun. 327 (2): 557–64. doi:10.1016/j.bbrc.2004.12.039. PMID 15629149.
• Dissen GA, Garcia-Rudaz C, Tapia V, et al. (2006). "Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary". Endocrinology. 147 (1): 155–65. doi:10.1210/en.2005-0386. PMID 16195402.