ISG20

ISG20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WLJ
Identifiers
Aliases	ISG20, CD25, HEM45, interferon stimulated exonuclease gene 20kDa, interferon stimulated exonuclease gene 20
External IDs	MGI: 1928895 HomoloGene: 31081 GeneCards: ISG20
Gene ontology Molecular function • 3'-5'-exoribonuclease activity • single-stranded DNA 3'-5' exodeoxyribonuclease activity • exoribonuclease II activity • metal ion binding • U3 snoRNA binding • U2 snRNA binding • RNA binding • nucleic acid binding • U1 snRNA binding • nuclease activity • exonuclease activity • hydrolase activity Cellular component • cytoplasm • Cajal body • PML body • nucleoplasm • nucleolus • nucleus Biological process • immune system process • response to virus • RNA catabolic process • negative regulation of viral genome replication • DNA catabolic process, exonucleolytic • defense response to virus • type I interferon signaling pathway • rRNA processing • innate immune response • cell proliferation • RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3669	57444
Ensembl	ENSG00000172183	ENSMUSG00000039236
UniProt	Q96AZ6	Q9JL16
RefSeq (mRNA)	NM_001303233 NM_001303234 NM_001303235 NM_001303236 NM_001303237 NM_002201	NM_001113527 NM_001291220 NM_001291221 NM_020583
RefSeq (protein)	NP_001290162.1 NP_001290163.1 NP_001290165.1 NP_002192.2	NP_001106999.1 NP_001278149.1 NP_001278150.1 NP_065608.2
Location (UCSC)	Chr 15: 88.64 – 88.66 Mb	Chr 7: 78.91 – 78.92 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Gongora C, David G, Pintard L, Tissot C, Hua TD, Dejean A, Mechti N (Aug 1997). "Molecular cloning of a new interferon-induced PML nuclear body-associated protein". The Journal of Biological Chemistry. 272 (31): 19457–63. doi:10.1074/jbc.272.31.19457. PMID 9235947.
4. Mattei MG, Tissot C, Gongora C, Mechti N (Jun 1998). "Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization". Cytogenetics and Cell Genetics. 79 (3-4): 286–7. doi:10.1159/000134745. PMID 9605874.
5. "Entrez Gene: ISG20 interferon stimulated exonuclease gene 20kDa".

Further reading

• Pentecost BT (Jan 1998). "Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus". The Journal of Steroid Biochemistry and Molecular Biology. 64 (1-2): 25–33. doi:10.1016/S0960-0760(97)00140-4. PMID 9569007.
• Nguyen LH, Espert L, Mechti N, Wilson DM (Jun 2001). "The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro". Biochemistry. 40 (24): 7174–9. doi:10.1021/bi010141t. PMID 11401564.
• Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (Feb 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Espert L, Degols G, Gongora C, Blondel D, Williams BR, Silverman RH, Mechti N (May 2003). "ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses". The Journal of Biological Chemistry. 278 (18): 16151–8. doi:10.1074/jbc.M209628200. PMID 12594219.
• Horio T, Murai M, Inoue T, Hamasaki T, Tanaka T, Ohgi T (Nov 2004). "Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease". FEBS Letters. 577 (1-2): 111–6. doi:10.1016/j.febslet.2004.09.074. PMID 15527770.