ITGA10

ITGA10
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1PT6, 1QC5, 1QCY, 2L8S, 2M32, 4A0Q
Identifiers
Aliases	ITGA10, PRO827, integrin subunit alpha 10
External IDs	MGI: 2153482 HomoloGene: 2697 GeneCards: ITGA10
Gene ontology Molecular function • metal ion binding • collagen binding involved in cell-matrix adhesion • collagen binding Cellular component • integrin complex • plasma membrane • membrane • integrin alpha10-beta1 complex • integral component of membrane Biological process • cell-matrix adhesion • extracellular matrix organization • cell adhesion • integrin-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8515	213119
Ensembl	ENSG00000143127	ENSMUSG00000090210
UniProt	O75578	n/a
RefSeq (mRNA)	NM_001303040 NM_001303041 NM_003637	NM_001081053 NM_001302471
RefSeq (protein)	NP_001289969.1 NP_001289970.1 NP_003628.2	n/a
Location (UCSC)	Chr 1: 145.89 – 145.91 Mb	Chr 3: 96.65 – 96.66 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.^[3][4][5]

Function

Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.^[3]

Related gene problems

• TAR syndrome^[6]
• 1q21.1 deletion syndrome
• 1q21.1 duplication syndrome

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: ITGA10 integrin, alpha 10".
4. Camper L, Hellman U, Lundgren-Akerlund E (August 1998). "Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes". J. Biol. Chem. 273 (32): 20383–9. doi:10.1074/jbc.273.32.20383. PMID 9685391.
5. Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization". Cytogenet. Cell Genet. 87 (3–4): 238–44. doi:10.1159/000015434. PMID 10702680.
6. Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

Further reading

• Camper L, Hellman U, Lundgren-Akerlund E (1998). "Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes". J. Biol. Chem. 273 (32): 20383–9. doi:10.1074/jbc.273.32.20383. PMID 9685391.
• Bengtsson T, Camper L, Schneller M, Lundgren-Akerlund E (2001). "Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants". Matrix Biol. 20 (8): 565–76. doi:10.1016/S0945-053X(01)00164-0. PMID 11731273.
• Brakebusch C, Hirsch E, Potocnik A, Fässler R (1997). "Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules". J. Cell. Sci. 110 (23): 2895–904. PMID 9359872.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Lehnert K, Ni J, Leung E, et al. (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization". Cytogenet. Cell Genet. 87 (3–4): 238–44. doi:10.1159/000015434. PMID 10702680.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Svoboda KK (1998). "Chondrocyte-matrix attachment complexes mediate survival and differentiation". Microsc. Res. Tech. 43 (2): 111–22. doi:10.1002/(SICI)1097-0029(19981015)43:2<111::AID-JEMT4>3.0.CO;2-O. PMID 9822998.
• Bengtsson T, Aszodi A, Nicolae C, et al. (2005). "Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes". J. Cell. Sci. 118 (Pt 5): 929–36. doi:10.1242/jcs.01678. PMID 15713743.
• Wenke AK, Rothhammer T, Moser M, Bosserhoff AK (2006). "Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1". Biochem. Biophys. Res. Commun. 345 (1): 495–501. doi:10.1016/j.bbrc.2006.04.123. PMID 16684505.

External links

• ITGA10 Info with links in the Cell Migration Gateway

This article incorporates text from the United States National Library of Medicine, which is in the public domain.