Intelectin-1

ITLN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WMQ, 4WMY
Identifiers
Aliases	ITLN1, HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin, intelectin 1
External IDs	MGI: 1333831 HomoloGene: 111044 GeneCards: ITLN1
Genetically Related Diseases
Crohn's disease[1]
Gene ontology Molecular function • carbohydrate binding Cellular component • extracellular region • membrane raft • anchored component of membrane • brush border membrane • receptor complex • plasma membrane • extracellular exosome • membrane Biological process • positive regulation of glucose import • positive regulation of protein phosphorylation • response to nematode Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55600	16429
Ensembl	ENSG00000179914	ENSMUSG00000038209
UniProt	Q8WWA0	O88310
RefSeq (mRNA)	NM_017625	NM_010584
RefSeq (protein)	NP_060095.2	NP_034714.1
Location (UCSC)	Chr 1: 160.88 – 160.89 Mb	Chr 1: 171.52 – 171.54 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1 gene.^[4][5][6] Intelectin-1 functions both as a receptor for bacterial arabinogalactans^[4] and for lactoferrin.^[7]

Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.^[8][9]

See also

• Intelectin

References

1. "Diseases that are genetically associated with ITLN1 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T (Jun 2001). "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall". J Biol Chem. 276 (26): 23456–63. doi:10.1074/jbc.M103162200. PMID 11313366.
5. Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M (Feb 2001). "Human homologs of the Xenopus oocyte cortical granule lectin XL35". Glycobiology. 11 (1): 65–73. doi:10.1093/glycob/11.1.65. PMID 11181563.
6. "Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding)".
7. Suzuki YA, Shin K, Lönnerdal B (December 2001). "Molecular cloning and functional expression of a human intestinal lactoferrin receptor". Biochemistry. 40 (51): 15771–9. doi:10.1021/bi0155899. PMID 11747454.
8. Wesener, Darryl A; Wangkanont, Kittikhun; McBride, Ryan; Song, Xuezheng; Kraft, Matthew B; Hodges, Heather L; Zarling, Lucas C; Splain, Rebecca A; Smith, David F; Cummings, Richard D; Paulson, James C; Forest, Katrina T; Kiessling, Laura L (6 July 2015). "Recognition of microbial glycans by human intelectin-1". Nature Structural & Molecular Biology. 22 (8): 603–610. doi:10.1038/nsmb.3053.
9. Wangkanont, K; Wesener, DA; Vidani, JA; Kiessling, LL; Forest, KT (11 January 2016). "Structures of Xenopus embryonic epidermal lectin reveal a conserved mechanism of microbial glycan recognition.". The Journal of Biological Chemistry. 291: 5596–610. doi:10.1074/jbc.M115.709212. PMID 26755729.

Further reading

• Suzuki YA, Lopez V, Lönnerdal B (2006). "Mammalian lactoferrin receptors: structure and function.". Cell. Mol. Life Sci. 62 (22): 2560–75. doi:10.1007/s00018-005-5371-1. PMID 16261254.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Chang BY, Peavy TR, Wardrip NJ, Hedrick JL (2004). "The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins". Comp. Biochem. Physiol., Part a Mol. Integr. Physiol. 137 (1): 115–29. doi:10.1016/S1095-6433(03)00269-1. PMID 14720597.
• Wali A, Morin PJ, Hough CD, Lonardo F, Seya T, Carbone M, Pass HI (2005). "Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE)". Lung Cancer. 48 (1): 19–29. doi:10.1016/j.lungcan.2004.10.011. PMID 15777968.
• Schäffler A, Neumeier M, Herfarth H, Fürst A, Schölmerich J, Büchler C (2006). "Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue". Biochim. Biophys. Acta. 1732 (1–3): 96–102. doi:10.1016/j.bbaexp.2005.11.005. PMID 16386808.
• Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW (2006). "Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action". Am. J. Physiol. Endocrinol. Metab. 290 (6): E1253–61. doi:10.1152/ajpendo.00572.2004. PMID 16531507.
• Schäffler A, Zeitoun M, Wobser H, Buechler C, Aslanidis C, Herfarth H (2007). "Frequency and significance of the novel single nucleotide missense polymorphism Val109Asp in the human gene encoding omentin in Caucasian patients with type 2 diabetes mellitus or chronic inflammatory bowel diseases". Cardiovascular diabetology. 6: 3. doi:10.1186/1475-2840-6-3. PMC 1802733. PMID 17295929.
• Wurm S, Neumeier M, Weigert J, Schäffler A, Buechler C (2007). "Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults". Cardiovascular diabetology. 6: 7. doi:10.1186/1475-2840-6-7. PMC 1804262. PMID 17311679.
• de Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, Ndubuizu K, Patil S, Schwartz A, Kligman M, Fried SK, Gong DW, Shuldiner AR, Pollin TI, McLenithan JC (2007). "Omentin plasma levels and gene expression are decreased in obesity". Diabetes. 56 (6): 1655–61. doi:10.2337/db06-1506. PMID 17329619.