ITM2A

ITM2A
Identifiers
Aliases	ITM2A, BRICD2A, E25A, integral membrane protein 2A
External IDs	MGI: 107706 HomoloGene: 31269 GeneCards: ITM2A
Gene ontology Molecular function • protein binding • beta-amyloid binding Cellular component • membrane • integral component of membrane • Golgi apparatus • extracellular exosome • plasma membrane Biological process • plasma cell differentiation • nervous system development • negative regulation of amyloid precursor protein biosynthetic process • immunoglobulin production Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9452	16431
Ensembl	ENSG00000078596	ENSMUSG00000031239
UniProt	O43736	Q61500
RefSeq (mRNA)	NM_004867 NM_001171581	NM_008409
RefSeq (protein)	NP_001165052.1 NP_004858.1	NP_032435.2
Location (UCSC)	Chr X: 79.36 – 79.37 Mb	Chr X: 107.4 – 107.4 Mb
PubMed search	[1]	[2]
Wikidata

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Integral membrane protein 2A is a protein that in humans is encoded by the ITM2A gene.^[3][4][5][6]

Function

The protein encoded by this gene is involved in osteo- and chondrogenic cellular differentiation (the cells which are responsible for the development of bone and cartilage respectively).^[4]

ITM2A is also involved in activation of T-cells in the immune system^[7] and in myocyte differentiation.^[8]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Pittois K, Wauters J, Bossuyt P, Deleersnijder W, Merregaert J (Mar 1999). "Genomic organization and chromosomal localization of the Itm2a gene". Mamm Genome. 10 (1): 54–6. doi:10.1007/s003359900942. PMID 9892734.
4. Deleersnijder W, Hong G, Cortvrindt R, Poirier C, Tylzanowski P, Pittois K, Van Marck E, Merregaert J (Sep 1996). "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins". J Biol Chem. 271 (32): 19475–82. doi:10.1074/jbc.271.32.19475. PMID 8702637.
5. "Entrez Gene: ITM2A integral membrane protein 2A".
6. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
7. Kirchner J, Bevan MJ (July 1999). "Itm2a Is Induced during Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4+Cd8+ Double Positive Thymocytes". J. Exp. Med. 190 (2): 217–28. doi:10.1084/jem.190.2.217. PMC 2195576. PMID 10432285.
8. Van den Plas D, Merregaert J (2004). "Constitutive overexpression of the integral membrane protein Itm2A enhances myogenic differentiation of C2C12 cells". Cell Biol. Int. 28 (3): 199–207. doi:10.1016/j.cellbi.2003.11.019. PMID 14984746.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Prashar Y, Weissman SM (1996). "Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 659–63. doi:10.1073/pnas.93.2.659. PMC 40108. PMID 8570611.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Mao M, Fu G, Wu JS, et al. (1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
• Kirchner J, Bevan MJ (1999). "Itm2a Is Induced during Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4+Cd8+ Double Positive Thymocytes". J. Exp. Med. 190 (2): 217–28. doi:10.1084/jem.190.2.217. PMC 2195576. PMID 10432285.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.

External links

• ITM2A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)