James Durham
James Durham may refer to:
- James Durham (baseball) (1881–1949), pitcher in Major League Baseball
- James R. Durham (1833–1904), Union Army officer and Medal of Honor recipient
- Jim Durham (1947–2012), American sportscaster
- James Derham (c. 1757–1802), also known as James Durham, the first African American to formally practice medicine in the United States
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