Jay McLean

Jay McLean (1890 – November 14, 1957) was an American physician. He is most notable for his major contribution to the discovery of heparin.

Early life

Born in San Francisco in 1890, he was the son of a physician, John T. McLean. Following education at Lowell High School, he entered the University of California at Berkeley in 1909, obtaining his Bachelor of Science degree in 1914.[1]

Career

McLean entered Johns Hopkins School of Medicine in 1915 where he met and began work with physiologist William Henry Howell. In 1916, when McLean was a second-year medical student, he was investigating pro-coagulant compounds when he first isolated a fat-soluble phosphatide anti-coagulant.[2] This anti-coagulant was first isolated from the liver tissue of canines, which is how Heparin got its name(hepar or "ήπαρ" is Greek for "liver"; hepar + -in), first coined in 1918.[3] Following the departure of McLean, Howell continued his work and with the assistance of T. Emmett Holt he isolated a water-soluble polysaccharide anticoagulant.[4] Howell also coined 'heparin' as the name of this compound despite being different from the compound previously discovered by McLean.[5]

McLean graduated from Johns Hopkins in 1919 and began an internship at the Johns Hopkins Hospital.[4] Following completion of his internship, he began a surgical residency, in which he rotated through the Hunterian Laboratory, the laboratory founded by Harvey Cushing in 1904.[6]

McLean stayed in Baltimore until 1924 when returned to his alma-mater, the University of California to become an instructor in surgery.[4] After three years in California, McLean took a position in the Department of Pathology at Cornell University, a position which he held until 1939.[4] After leaving Cornell, McLean moved to Columbus, Ohio, where he worked in private surgical practice and was appointed as an associate professor of surgery at Ohio State medical school.[4] In 1949, he was appointed director of Radiation Therapy and Consultant in Malignant Diseases in Savannah, Georgia, where he remained until his death in 1957, aged 67 years.[4]

References

  1. ↑ MCLEAN, J. (1 January 1959). "The Discovery of Heparin". Circulation. 19 (1): 75–78. doi:10.1161/01.CIR.19.1.75. PMID 13619023.
  2. ↑ McLean J (1916). "The Thromboplastic Action of Cephalin". American Journal of Physiology.
  3. ↑ Mueller RL, Scheidt, S (1994). "History of drugs for thrombotic disease. Discovery, development, and directions for the future.". Circulation. 89(1): 432–449. PMID 8281678.
  4. 1 2 3 4 5 6 Couch NP (1989). "About heparin, or ... whatever happened to Jay McLean?". J. Vasc. Surg. 10 (1): 1–8. PMID 2664233.
  5. ↑ "ajplegacy.physiology.org".
  6. ↑ Sampath P, Long DM, Brem H (2000). "The Hunterian Neurosurgical Laboratory: the first 100 years of neurosurgical research". Neurosurgery. 46 (1): 184–94; discussion 194–5. PMID 10626949.
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